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Efficacy of hydroxychloroquine against Wuhan virus


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2020 Mar 21, 10:47am   11,860 views  290 comments

by Patrick   ➕follow (59)   💰tip   ignore  

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81   CBOEtrader   2020 Mar 28, 2:54pm  

Ceffer says
Trump isn't a doctor, but he is visibly trying to do the right thing and talking person-to-person with the public on a human level. The so-called doctors in charge are bizarre political creatures with murky agendas.


Fausi seems to be doing a decent job
83   RWSGFY   2020 Mar 28, 3:13pm  

Patrick says
Or maybe it was created by, say, Russia, just to get the US and China to go at each other.


There was a big fire in Russian bioweapons lab in Novosibirsk last September. Novosibirsk is right on the border with China and cross-border trade is pretty lively there. So maybe that shit escaped during the fire and got carried by Chinese laborers back to China.
84   rdm   2020 Mar 28, 3:24pm  

WookieMan says

He then also shouldn't talk economics. Or legislation. Taxes


Agree.

Trump is a promoter, he really knows very little about anything but promotion.
85   theoakman   2020 Mar 28, 5:59pm  

It was a really good interview. Basically, you can tell, he's actively doing great research. Most doctors aren't willing to do that and they just want to be told what to do from a manual or from above.
86   Rin   2020 Mar 28, 6:52pm  

theoakman says
It was a really good interview. Basically, you can tell, he's actively doing great research. Most doctors aren't willing to do that and they just want to be told what to do from a manual or from above.


He's also a creative thinker as he added Zinc Sulfate, so that the Hydroxychloroquine can be a carrier of its Zinc ion into the intercellular space of the infected cell instead of wasting time on the surface where Zinc's antiviral effects are wasted. That's why most Zinc lozenges aren't useful.

That's having the ability to think outside the box, which many ass kissing establishment types like Fauci can't do.

He was also smart in the sense that he didn't say if the Azithromycine had any antiviral effects and only focused on its effects on opportunistic infections.

This is a real doctor, not a stereotypical Oxycontin pushing douchebag.
87   Booger   2020 Mar 29, 6:35am  

The $20 hydroxychloroquine cocktail has a 98% success rate but Bill Gates and the media want to cash out on a vaccine and make trillions. CHINA-19 has already been defeated
88   Tenpoundbass   2020 Mar 29, 6:55am  

Bill Gates wants to drag this out until next year. He's really pissed off that the cure came so untimely for them. He had this big elaborate coronation planned where he was going to be nominated the king of the world, or the head of the UN one government. I mean he told the janitor at Microsoft, "pshaw! you can have that old thing! I'm moving on up to the Big BIG office!" He was talking about his office and parking spot at Redmond.

Fucking meddling do gooder Doctors finding actual cures and stuff. What a waste of a perfectly good global crisis.

I'm curious if Liberals actually think Historians will look back at this and in spite of all of the record of Trump going above and beyond his duty, and the tireless work his whole task force is doing. The Liberals keep saying Trump isn't doing shit, and he's making things worse. Do these clowns think they'll be portrayed as some kind of voice of reason in the Historic record?
I think they are going sing Trump praises for his restraint, History will wonder why all of the TDS saboteurs and seditious dissidents weren't rounded up and dispatched.
90   Rin   2020 Mar 29, 8:33am  

Booger says
Bill Gates and the media want to cash out on a vaccine and make trillions.


Let me sum it up in one word ... DOUCHEBAGS!!!

Tenpoundbass says
Bill Gates wants to drag this out until next year.


This is why I was never impressed at his Bill & Melinda society because all it was, was a discount Rx program for the third world, not an organization to actually solve real medical issues, something which our greater NYC doctor is doing every single day.
91   Patrick   2020 Mar 29, 9:55am  

https://www.trustnodes.com/2020/03/28/debate-ends-over-chloroquine-as-france-officially-sanctions-usage

Days after beginning a large scale double blinded trial, the so called gold standard, France has now reached the conclusion chloroquine is recommended to treat corona.

Speaking at a news conference, Jérôme Salomon (pictured), France’s director general of health, said the officially sanctioned prescriptions of chloroquine to treat corona “allows a temporary authorization to allow certain patients with coronavirus to benefit from this therapeutic route.”

Doctors in France now will finally be able to treat patients with Didier Raoult, a renown doctor that specializes in infectious diseases, announcing new clinical results that show out of 80 patients treated with chloroquine, 78 recovered within 5 days.

That’s considerably more than the usual 14 days and for some it can go up to 28 days if they recover at all. ...

In UK the government has prohibited its use outside of trial, but that position is probably untenable now as they have to explain why they are not treating patients as France is doing.

The hope is that once general treatment is given, and preferably early treatment, this situation can be contained as in South Korea or in China or in much of Asia.


Note that both China and South Korea officially recommend hydroxychloroquine for Wuhan virus disease, and have a low rate of deaths now.
92   Tenpoundbass   2020 Mar 29, 10:01am  

Patrick says
Doctors in France now will finally be able to treat patients with Didier Raoult, a renown doctor that specializes in infectious diseases, announcing new clinical results that show out of 80 patients treated with chloroquine, 78 recovered within 5 days.

That’s considerably more than the usual 14 days and for some it can go up to 28 days if they recover at all. .


Friday is a long way away in the scheme of a Global Hoax Pandemic being exposed goes.

It will quite honestly be possible that by next Sunday(Easter) The world's attitude is, everybody back to work. If you get it, then there's a cure.


The Globalist are going to be livid. Where 2 out of 1000 people might get the Virus, and only two people buy a $20.00 treatment. They were demanding a Vaccine, that would require every man woman and child on Earth have to take their Yearly dose of a COVID19 Vaccine. Anthony Fauci was banking on it. Fuck now he's going to lose his HOUSE!

Yes this is about money and a lot hinging on the investment of the Vaccine, nobody expected a cure so soon. Not even HalfWitt.
93   Patrick   2020 Mar 29, 10:08am  

Iran's clearly flattening curves may also reflect their use of hydroxychloroquine:



Why is it taking so long for additional studies to come out, positive or negative?
94   CBOEtrader   2020 Mar 29, 10:45am  

Tenpoundbass says
Where 2 out of 1000 people might get the Virus, and only two people buy a $20.00 treatment.


Less than that. The doctor suggests only immuno compromised should risk the toxicity, saying it's better for everyone healthy and under 60 years old to let your immune system do its job.

That probably means a vaccine will still be in the market and widely used within 18 months.
95   MisdemeanorRebel   2020 Mar 29, 11:13am  

Patrick says
Days after beginning a large scale double blinded trial, the so called gold standard, France has now reached the conclusion chloroquine is recommended to treat corona.


Tenpoundbass says
The Globalist are going to be livid. Where 2 out of 1000 people might get the Virus, and only two people buy a $20.00 treatment. They were demanding a Vaccine, that would require every man woman and child on Earth have to take their Yearly dose of a COVID19 Vaccine. Anthony Fauci was banking on it. Fuck now he's going to lose his HOUSE!


96   mell   2020 Mar 29, 12:55pm  

ThreeBays says
Patrick says
Days after beginning a large scale double blinded trial, the so called gold standard, France has now reached the conclusion chloroquine is recommended to treat corona.


That's great news.

One issue is there was no double blinded trial data here, and this article is just referencing Didier Raoult's badly fudged study. https://forbetterscience.com/2020/03/26/chloroquine-genius-didier-raoult-to-save-the-world-from-covid-19/?fbclid=IwAR02EUmH1FUjNVZXWrAGB0bfzpCDQ-v0l5Wx7WzywVwCVyUdP1LNhflDlDM

Why are chloroquine studies only popping up from fairly shady sources?


If the French and other European countries are using it now I doubt the studies aren't truthful.
97   mell   2020 Mar 29, 1:12pm  

ThreeBays says
mell says
If the French and other European countries are using it now I doubt the studies aren't truthful.


The French have approved it for use for certain COVID-19 patients. Is there more information?

https://www.france24.com/en/20200329-french-expert-says-second-study-shows-malaria-drug-helps-fight-coronavirus


Fakemed, a group of scientists against fake news in health, lambasted the 68-year-old professor.

After Raoult released his latest findings on the internet over the weekend, Professor Francois Balloux of University College, London, tried to dampen talk that the drug could be a silver bullet.

"No, (this is) not 'huge' I'm afraid," he said on Twitter.

"This is an observational study (i.e. not controlled) following...


That must be why MDs are stockpiling it for their families here in the US while telling patients it's not effective. From all the material I read so far I'm convinced it's effective enough to make a big difference.
98   CBOEtrader   2020 Mar 29, 1:15pm  

mell says
If the French and other European countries are using it now I doubt the studies aren't truthful.


Pretty sure they are corner cutting, but also only prescribing this to at risk patients for whom CV is a very possible death sentence.

I wouldnt expect the proper studies to be completed for months
99   mell   2020 Mar 29, 1:25pm  

CBOEtrader says
mell says
If the French and other European countries are using it now I doubt the studies aren't truthful.


Pretty sure they are corner cutting, but also only prescribing this to at risk patients for whom CV is a very possible death sentence.

I wouldnt expect the proper studies to be completed for months


Agreed.

ThreeBays says
I'm hopeful this is real because that would save a lot of lives and get us back to normal, but I'm not finding any material that's very convincing that this is a silver bullet yet.

This French guy's study isn't controlled or large enough to really tell much.

Dr. Vladmir Zelenko's data is also pretty weird. It sounds like he did most of his protocol between Tuesday and Thursday last week, and by Monday he was already declaring victory and writing a letter to Trump. Weird A/F.


Long term studies take too much time in this scenario. It doesn't matter if it's only partially effective, if it helps keeping even just 20% of people off the ICU it's a huge win.
100   socal2   2020 Mar 29, 1:30pm  

We should know alot more this week with all of the trials going on in New York.

This thread is VERY encouraging from one of the doctors treating hundreds of paitents with it with ZERO deaths so far..
https://twitter.com/KMCRadio/status/1243439036917841920
101   CBOEtrader   2020 Mar 29, 1:31pm  

According to that NY doctor, if you are younger than 60 and healthy, you get to fight through your resulting CV illness. You wont get this drug unless your symptoms progress to a dangerous level. It sounds miserable, and takes about 10 days from start of symptoms until it subsides
103   theoakman   2020 Mar 29, 7:32pm  

Why do people think it's a far fetched idea that an anti-viral medication would have a positive effect on faster recovery?
104   Patrick   2020 Mar 29, 8:26pm  

theoakman says
Why do people think it's a far fetched idea that an anti-viral medication would have a positive effect on faster recovery?


Because Trump suggested it.
105   Patrick   2020 Mar 29, 9:15pm  

https://in.reuters.com/article/health-coronavirus-novartis/novartis-ceo-says-malaria-drug-is-biggest-hope-against-coronavirus-sonntagszeitung-idINKBN21G06O?utm_source=patrick.net

ZURICH (Reuters) - Novartis Chief Executive Vas Narasimhan said his Sandoz generics unit’s malaria, lupus and arthritis drug hydroxychloroquine is the company’s biggest hope against the coronavirus, Swiss newspaper SonntagsZeitung reported on Sunday. ...

“Pre-clinical studies in animals as well as the first data from clinical studies show that hydroxychloroquine kills the coronavirus,” Narasimhan told the newspaper. “We’re working with Swiss hospitals on possible treatment protocols for the clinical use of the drug, but it’s too early to say anything definitively.”

He said the company is currently looking for additional active drug ingredients to make more hydroxychloroquine, should clinical trials be successful.
107   mell   2020 Mar 29, 9:28pm  

Heraclitusstudent says
You guys are paranoiac cultists.
There is a method to test drugs and doctors insist on following the method.
If you don't like modern medicine, visit your witch doctor.


Certainly not during a pandemic. You naturally try and give leeway to known antivirals and skip the usually required lengthy clinical trials. When your house is on fire you don't wait for a certified water hose, you throw at it what you have. Btw. one of Trumps first signing was the 21st century cures act which allows terminally ill or disabled patients to try potential new cures without waiting for years of phase 3 trials. Not everything orange man does is bad and he may win on chloroquine as well. There's a reason MDs have been stockpiling it for their families while telling patients it's too risky.
108   richwicks   2020 Mar 29, 9:35pm  

Tenpoundbass says
He shouldn't propose unproven drugs. That was a very STUPID thing to do.


Let science take care of itself. It is a hypothesis that he's presented. We'll find out in time if it's correct or incorrect. Let the medical and scientific community report on the efficacy.
110   Patrick   2020 Mar 29, 9:45pm  

mell says
https://www.google.com/amp/s/www.wsj.com/amp/articles/an-update-on-the-coronavirus-treatment-11585509827


In the fight against Covid-19 though we might look forward in doom, one day we will look backward in awe. In an article last week, I discussed a promising drug combination to treat the disease. There is now new data supporting this treatment. Since then, Kansas City area physicians, including Joe Brewer, Dan Hinthorn and me, continue to treat many patients, and some have shown improvement. Major medical centers including the University of Washington and Mass General have added hydroxychloroquine to treatment options. So here’s an update, a response to some questions that have come up, and suggestions based on the latest...

Clinical information has also emerged from Covid treatment. During the initial Chinese outbreak, Wuhan doctors observed that patients with lupus—a disease for which HC is a common treatment—did not seem to develop Covid-19. Of 178 hospital patients who tested positive, none had lupus and none were on HC. None of this Wuhan hospital’s dermatology department’s 80 lupus patients were infected with the novel coronavirus. The Wuhan doctors hypothesized that this may be due to long-term use of HC. They treated 20 Covid-19 patients with HC. Their result: “Clinical symptoms improve significantly in 1 to 2 days. After five days of chest CT examination, 19 cases showed significant absorption improvement.” ...

The World Health Organization lists both HC and AZ as essential medicines, “considered to be the most effective and safe to meet the most important needs in a health system.” These drugs have been in use for many years—HC since 1955 and AZ since 1988. Only the combination is new. For now it isn’t well understood why the mix is so effective.

The clinical information service Lexicomp lists the interaction between HC and AZ as Category B, which means the majority of patients require no special caution. Long-term HC use can have adverse effects. Chronic use can cause eye problems, Heartbeat arrhythmia is occasionally observed. Increased electrocardiogram tracking may be appropriate for patients at risk of the latter effect. Potential mental-health effects should be closely observed.

All drugs have side effects, and HC’s overall record is safe. Yes, this is an “off label” use. But that isn’t unusual, either. One study showed 21% of U.S. prescriptions were for off-label use.

These drugs are still needed to treat malaria, lupus and other diseases, which makes it important not to exhaust supplies treating Covid-19 patients. Yet this is a historic pandemic, and treatment with HC and AZ shows considerable promise. That is reason to increase supplies quickly. ...

For my entire career, I have taken a conservative approach to medicine. I don’t want to give false or premature hope. All of this is subject to further refinement as more information arrives. But likewise I can’t ignore the available evidence. This appears to be the best widely available option for treating Covid-19 and not merely easing the suffering from the disease. It would be irresponsible not to pursue this option aggressively.


Gosh, sounding more and more like hydroxychloroquine + azithromycin does in fact help. A lot.

#TrumpPills
111   Patrick   2020 Mar 29, 10:13pm  

An as-yet unpublished letter:

https://www.sciencedirect.com/science/article/pii/S1871402120300515

A Chinese study involving more than 100 patients of COVID-19 found chloroquine superior to the control group in reducing symptom duration, exacerbation of pneumonia including radiological improvement and promoting virus-negative seroconversion without any severe side effects [18]. This represents the first human trial ever conducted with chloroquine against COVID-19. Although the detailed results of this trial are not yet published and only available in a letter form, interestingly, this early result led China to include chloroquine in the prevention and treatment of COVID-19 pneumonia. Moreover, The National Health Commission of the People's Republic of China recommended inclusion of chloroquine in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19. In this study, chloroquine was given in dose of 500 mg of chloroquine twice daily in mild to severe COVID-19 pneumonia. ...

Although there are sporadic case reports of chloroquine-induced cardiomyopathy and reversible heart failure in the literature, many studies and large meta-analysis conducted in patients with rheumatoid arthritis pointed to a reduced cardiovascular risk with both these compounds [40]. Nevertheless, since both the drug has potential to prolog QTc, a baseline ECG should be done in patients with established cardiovascular disease.
112   Patrick   2020 Mar 29, 10:14pm  

ChicagoAnalytic
@AnalyticChicago

Quick update-- news that FDA is granting emergency authorization 4 hospitals 2 use #chloroquine & #Hydroxychloroquine w hospitalized patients seems to b signaling at least a slight de-escalation of circumstances, and giving #markets an early bump off lows


Here's the FDA approval note:

https://www.fda.gov/media/136537/download
113   Patrick   2020 Mar 29, 10:17pm  

Article from 2005 showing "potent" chloroquine efficacy against the related SARS virus:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/
114   MisdemeanorRebel   2020 Mar 30, 7:28am  

r/Coronavirus commenters, two weeks ago, before Trump mentioned Treatment. "Superior Technocratic Belgium is using Chloroquine! It must be good! Why don't we? Big Pharma, Backward AmeriKKKa!"

https://archive.fo/W9Xjk
116   HeadSet   2020 Mar 30, 8:13am  

Virginia Commonwealth University is now doing clinical trials using remdesivir, an antiviral medication previously used experimentally to treat the Ebola virus. Several VCU Health System patients with moderate to severe cases of COVID-19 have been treated with remdesivir with very encouraging results. Still early in testing, though.

Redesivir was invented by Gilead Sciences Inc, which is one of your smart California companies. I suspect that throughout the world, other older drugs used to treat various viral diseases are being dusted off and tried against COVID-19.
117   Rin   2020 Mar 30, 2:49pm  

Patrick says
sporadic case reports of chloroquine-induced cardiomyopathy


What's silly about this, whenever the press reports on it, is that any doctor can give a baseline EKG and re-run it after a patient takes 100 mg to determine its safety for a given patient. If the patient can't handle it then unfortunately, he's one of the unlucky 1% who can't get the therapy. In other words, for the other 99%, they would be fine. And thus, the virus' mortality will be 0.034 (according to WHO but debatable) x 0.01 or 0.00034
118   Patrick   2020 Mar 30, 8:14pm  

https://thefederalist.com/2020/03/30/twitter-removes-tweet-reporting-hydroxychloroquine-as-treatment-for-wuhan-virus/

Twitter removed a tweet from Fox New host Laura Ingraham that suggested hospitals using hydroxychloroquine as treatment for the Wuhan coronavirus are showing promising results, despite the FDA’s approval of the drug for emergency use.

“Lenox Hill in New York among many hospitals already using hydroxychloroquine with very promising results. One patient was described as ‘Lazarus’ who was seriously ill from Covid-19, already released,” Ingraham tweeted.
119   joshuatrio   2020 Mar 31, 4:27am  

Patrick, thanks for staying on top of this. This seems like a reasonable solution to CV. Nice to a know a old and cheap prescription actually works on this.
120   CBOEtrader   2020 Mar 31, 6:22am  

joshuatrio says
Patrick, thanks for staying on top of this. This seems like a reasonable solution to CV. Nice to a know a old and cheap prescription actually works on this.


Self quarantine would break down if they announced a $20 cure.

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