patrick.net

Drink whatever you want. Slosh 'em down in front of your kids at dinner. Just drop the pretense that it has anything to do with 'good health'. Promoting your own habits as 'good health' for the industries and their propagandas is free advertising for them.

I can't count the times people have offered me dope, drink, or cigarettes in the past dozens of years. Users like company and like justification. The vendors are happy to provide the mythologies, even wearing the white coats and stethescopes. Whore doctors and fake scientists are a dime a dozen these days.

I just wish ONCE somebody would say "I read this fake study, and it's all bullshit, but I am still going to do what I want to do because it feels good and I am habituated. I will live with the consequences and know that they publish bullshit to massage my need."

I poisoned myself with turmeric and pepper for a couple of months a few years ago, sprinkling that on food at most meals.

Was giving me headaches, malaise, and swollen feet.

When I stopped, the problems went away.

I’m pretty sure it was a kind of liver damage.

I poisoned myself with turmeric and pepper for a couple of months a few years ago, sprinkling that on food at most meals.

Was giving me headaches, malaise, and swollen feet.

When I stopped, the problems went away.

I've been taking Turmeric capsules for a couple years now and have had no adverse problems. My lower back and knees have been feeling great with less inflamation and also hope it is helping keep any cancer at bay with my family's history. I was unaware there were any negative health effects other than nausea if you take too much on an empty stomach.

I poisoned myself with turmeric and pepper for a couple of months a few years ago, sprinkling that on food at most meals.

Was giving me headaches, malaise, and swollen feet.

When I stopped, the problems went away.

I’m pretty sure it was a kind of liver damage.

Evidence of turmeric adulteration with lead chromate across South Asia

Highlights
•Pb and Cr concentrations of turmeric across South Asia
•Pb:Cr molar ratio indicates PbCrO4 adulteration versus environmental contamination
•Pb levels >500 times higher than regulatory limit in India, Pakistan, and Nepal
•Projected blood lead levels exceed reference levels by >10-fold due to turmeric
•Spices represent an understudied source of lead poisoning globally

The mix includes lead chromate, which is also bright yellow, and highly neurotoxic.

HLA typing demonstrated that 7 patients carried HLA-B*35:01, 2 of whom were homozygous, yielding an allele frequency of 0.450 compared with population controls of 0.056-0.069.

Conclusion

Liver injury due to turmeric appears to be increasing in the United States, perhaps reflecting usage patterns or increased combination with black pepper. Turmeric causes potentially severe liver injury that is typically hepatocellular, with a latency of 1 to 4 months and strong linkage to HLA-B*35:01.

Yellow Prussiate of Soda

Despite containing cyanide ligands, it has low toxicity because it does not readily release free cyanide under normal conditions; the acceptable daily intake is 0–0.025 mg/kg body weight. However, exposure to strong acids or UV light can lead to the formation of highly toxic hydrogen cyanide gas.

Al_Sharpton_for_President says

Yellow Prussiate of Soda

Yes, that's strange. Don't let sunlight shine on it:

Despite containing cyanide ligands, it has low toxicity because it does not readily release free cyanide under normal conditions; the acceptable daily intake is 0–0.025 mg/kg body weight. However, exposure to strong acids or UV light can lead to the formation of highly toxic hydrogen cyanide gas.

How many Frankenstein potions hide behind the GRAS (generally regarded as safe) category?

Like pH 2 stomach acid.

Acetaldehyde → Acetate (via aldehyde dehydrogenase, or ALDH enzyme, primarily ALDH2 in mitochondria): Acetaldehyde is rapidly converted to acetate (acetic acid), which is much less toxic and harmless in small amounts.

Acetate is then further broken down into water and carbon dioxide (or used for energy via the Krebs cycle).

The critical factor is that ALDH is extremely efficient in most people:It has a very low Km (high affinity for acetaldehyde), meaning it works quickly even at low concentrations.

Acetaldehyde levels remain very brief and low (typically in the micromolar range, e.g., ~1–5 μM in normal individuals after moderate drinking).

Dose matters hugely: Moderate intake (e.g., 1–2 standard drinks) produces acetaldehyde at levels the body's ALDH can handle quickly. The toxin is detoxified almost as fast as it's produced.

Alcohol in the body is converted to acetyl aldehyde, which is poisonous.

Aldehydes are all toxic; would you drink a shot glass of formaldehyde (formalin)?

There is no level of alcohol consumption which is entirely safe; how much poison you like your body to process is up to you.

Why do you have a hangover?
Because you consumed a toxic chemical previously.

Acetate is then further broken down into water and carbon dioxide (or used for energy via the Krebs cycle).

Too much of it.

Patrick says

Too much of it.

If you can feel any effects, that is enough to do damage.

Light drinkers have a lower risk of premature death compared to teetotalers, according to multiple studies analyzing large populations. A key study published in PLOS Medicine using data from nearly 100,000 U.S. adults aged 55 to 74 found that individuals who consumed seven alcoholic drinks per week—about one drink per day—had the lowest combined risk of dying or developing cancer over a nine-year period. This group showed a 7% lower risk of early death or cancer diagnosis compared to lifelong teetotalers.

However, this protective effect is seen only in light drinkers. Heavier drinking—three drinks per day—increased the risk of cancer or premature death by 20%.