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Study reveals 'consistent association' between genital talc, ovarian cancer.
invite response
2024 May 19, 6:51am 241 views 10 comments
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3
Tenpoundbass
2024 May 19, 10:26am
Tenpoundbass
2024 May 19, 10:26am
Johnson and Johnson were sued 10 or 20 years ago over the cause of crotch cancer in men.
What did they leave money on the table?
Talc has been removed from baby powder since.
What did they leave money on the table?
Talc has been removed from baby powder since.
4
Tenpoundbass
2024 May 19, 10:27am
Tenpoundbass
2024 May 19, 10:27am
Also talc has been used in body and face powder for centuries. It's not like Johnson and Johnson invented it.
How can they sued for continuing a tradition and formula that had been used for generations, and by other companies?
How can they sued for continuing a tradition and formula that had been used for generations, and by other companies?
5
Tenpoundbass
2024 May 19, 10:30am
Tenpoundbass
2024 May 19, 10:30am
From Wiki above it says it's used in Cancer treatment, the next passage says it causes Cancer...
Sterile talc powder
Sterile talc powder (NDC 63256-200-05) is a sclerosing agent used in the procedure of pleurodesis. This can be helpful as a cancer treatment to prevent pleural effusions (an abnormal collection of fluid in the space between the lungs and the thoracic wall). It is inserted into the space via a chest tube, causing it to close up, so fluid cannot collect there. The product can be sterilized by dry heat, ethylene oxide, or gamma irradiation.[22]
Safety
Suspicions have been raised that talc use contributes to certain types of disease, mainly cancers of the ovaries and lungs. According to the IARC, talc containing asbestos is classified as a group 1 agent (carcinogenic to humans), talc use in the perineum is classified as group 2B (possibly carcinogenic to humans), and talc not containing asbestos is classified as group 3 (unclassifiable as to carcinogenicity in humans).[23] Reviews by Cancer Research UK and the American Cancer Society conclude that some studies have found a link, but other studies have not.[24][25]
The studies discuss pulmonary issues,[26] lung cancer,[27][28] and ovarian cancer.[29] One of these, published in 1993, was a US National Toxicology Program report, which found that cosmetic grade talc containing no asbestos-like fibres was correlated with tumor formation in rats forced to inhale talc for 6 hours a day, five days a week over at least 113 weeks.[27] A 1971 paper found particles of talc embedded in 75% of the ovarian tumors studied.[30] Research published in 1995 and 2000 concluded that it was plausible that talc could cause ovarian cancer, but no conclusive evidence was shown.[31][32] The Cosmetic Ingredient Review Expert Panel concluded in 2015 that talc, in the concentrations currently used in cosmetics, is safe.[33] In 2018, Health Canada issued a warning, advising against inhaling talcum powder or using it in the female perineal area.[34]
Sterile talc powder
Sterile talc powder (NDC 63256-200-05) is a sclerosing agent used in the procedure of pleurodesis. This can be helpful as a cancer treatment to prevent pleural effusions (an abnormal collection of fluid in the space between the lungs and the thoracic wall). It is inserted into the space via a chest tube, causing it to close up, so fluid cannot collect there. The product can be sterilized by dry heat, ethylene oxide, or gamma irradiation.[22]
Safety
Suspicions have been raised that talc use contributes to certain types of disease, mainly cancers of the ovaries and lungs. According to the IARC, talc containing asbestos is classified as a group 1 agent (carcinogenic to humans), talc use in the perineum is classified as group 2B (possibly carcinogenic to humans), and talc not containing asbestos is classified as group 3 (unclassifiable as to carcinogenicity in humans).[23] Reviews by Cancer Research UK and the American Cancer Society conclude that some studies have found a link, but other studies have not.[24][25]
The studies discuss pulmonary issues,[26] lung cancer,[27][28] and ovarian cancer.[29] One of these, published in 1993, was a US National Toxicology Program report, which found that cosmetic grade talc containing no asbestos-like fibres was correlated with tumor formation in rats forced to inhale talc for 6 hours a day, five days a week over at least 113 weeks.[27] A 1971 paper found particles of talc embedded in 75% of the ovarian tumors studied.[30] Research published in 1995 and 2000 concluded that it was plausible that talc could cause ovarian cancer, but no conclusive evidence was shown.[31][32] The Cosmetic Ingredient Review Expert Panel concluded in 2015 that talc, in the concentrations currently used in cosmetics, is safe.[33] In 2018, Health Canada issued a warning, advising against inhaling talcum powder or using it in the female perineal area.[34]
Genital talc, douching had positive associations with ovarian cancer.
Neither intimate care product had associations with breast or uterine cancer.
Genital talc powder use increased risk for ovarian cancer in cohort of women, according to study results published in Journal of Clinical Oncology.
Additionally, frequent douching and douching during young adulthood also had associations with increased ovarian cancer risk.
“Despite challenges in assessing exposure history and biases inherent in retrospective data, our findings are robust, showing a consistent association between genital talc use and ovarian cancer,” Katie M. O’Brien, PhD, MSPH, researcher at the epidemiology branch of the National Institute of Environmental Health Sciences, said in an ASCO-issued press release. “This study leverages detailed lifetime exposure histories, and the unique design of the Sister Study, to provide more reliable evidence that supports a potential association between long-term and frequent genital talc use and ovarian cancer.”
Previous studies have examined associations between intimate care products, particularly talc and ovarian cancer, but “recall bias and exposure misclassification” clouded findings, according to background information provided by the researchers.
O’Brien and colleagues accounted for these potential limitations by conducting a quantitative bias analysis of the potential risks intimate care products have on developing hormone-related cancers. They used data from the prospective Sister Study, which enrolled 50,884 women who had a sister with breast cancer.
Collection of participants’ genital talc use and douching habits took place during enrollment from 2003 to 2009 and follow-up from 2017 to 2019.
Over the timeframe of the study, 35% to 56% of the examined cohort used genital talc and 41% to 64% of the cohort douched.
Genital talc had positive associations with ovarian cancer (HR = 1.17-3.34). Even after adjusting for positive biases, HRs still eclipsed 1.
Neither genital talc use nor douching had associations with uterine or breast cancer.
“This study underscores the potential risks associated with intimate care products, particularly genital talc,” Fumiko Chino, MD, radiation oncologist at Memorial Sloan Kettering Cancer Center and a member of Healio’s Women in Oncology Peer Perspective Board, said in the release. “The evidence adds to a growing body of literature that suggests such products could contribute to an increased risk [for] ovarian cancer, especially among frequent users and those using these products in their 20s and 30s.”
https://www.healio.com/news/hematology-oncology/20240516/study-reveals-consistent-association-between-genital-talc-ovarian-cancer