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Efficacy of hydroxychloroquine against Wuhan virus


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2020 Mar 21, 10:47am   11,866 views  290 comments

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240   Rin   2020 Apr 8, 1:50pm  

Shaman says
Heraclitusstudent says
Ahh republican ethics in 2020.....

Donald Trump Has Stake In Hydroxychloroquine Drugmaker
https://www.yahoo.com/news/donald-trump-stake-company-hydroxychloroquine-112913777.html

I love it when my company makes me take a class on conflict on interests every 2 years.


That is total bullshit. If you weren’t so fucking blinded by hate you’d see this as the fake news story that it is. Part of a mutual fund worth maybe $100 is invested in that company. Fuck! I probably have investment in that one too via my own mutual funds! I don’t even know. So how the fuck would Trump know? And he wipes his ass with $100 dollar bills.
Time to grow up and start thinking critically.


And being a top international drug company, it's in Pharma based ETFs which means that a lot of the unaware investing public has some exposure to it, not just Trump & Co.

And given the fact that it's a generic, the profit margins are already low so it's not even a target novel agent for a major cap gains which is why places like Vertex are always searching tor a more patent-able and thus, more expense new drug lines.
241   Bd6r   2020 Apr 8, 3:07pm  

marcus says
I never thought that it doesn't work. Only that it's very difficult to tell, when recovery rates are over 90% anyway, and that many studies say there is little good evidence that it does. I was wishing that it does, and couldn't care less whether Trump get's credit for pushing it.

I'm not pointing at you, @marcus, I feel that you can be argued with rationally for most
242   mell   2020 Apr 8, 3:32pm  

Rin says
Shaman says
Heraclitusstudent says
Ahh republican ethics in 2020.....

Donald Trump Has Stake In Hydroxychloroquine Drugmaker
https://www.yahoo.com/news/donald-trump-stake-company-hydroxychloroquine-112913777.html

I love it when my company makes me take a class on conflict on interests every 2 years.


That is total bullshit. If you weren’t so fucking blinded by hate you’d see this as the fake news story that it is. Part of a mutual fund worth maybe $100 is invested in that company. Fuck! I probably have investment in that one too via my own mutual funds! I don’t even know. So how the fuck would Trump know? And he wipes his ass with $100 dollar bills.
Time to...


100% agreed it's so cheap with such low margins that cos literally give it away. The pump and dump is in "novel" drugs and vaccines.
243   WookieMan   2020 Apr 8, 5:02pm  

Patrick says
It seems likely that the rich and the people with political power (usually the same) are mostly old, and afraid for their own health. Most people end up with one "comorbidity" or another by the age of 75. So they burn down the economy out of fear.

Hence why I've recommended age limits for politicians. We have floors age wise for House reps, Senators and POTUS. For some reason it's okay to work until you're completely fucking senile. Term limits and old age limits would be a massive step in the right direction.

I'm not even super tech savvy, but I'd doubt most 50 year olds could even set up a domain name and wordpress themed site without having to hire someone. If you don't understand what the fuck you're legislating to some extent, we've got a god damn problem.
244   HeadSet   2020 Apr 8, 5:44pm  

For some reason it's okay to work until you're completely fucking senile.

Because at the time this was set up, the founders figured the voters would not elect a senile type like Biden. Remember, voting was limited to property owners who were electing one of their own to do a temporary job and then get back to farm or business. Since we now have universal voting rights, where even an illiterate can cast a ballot, we do need term limits and maximum age.
245   mell   2020 Apr 8, 5:48pm  

HeadSet says
For some reason it's okay to work until you're completely fucking senile.

Because at the time this was set up, the founders figured the voters would not elect a senile type like Biden. Remember, voting was limited to property owners who were electing one of their own to do a temporary job and then get back to farm or business. Since we now have universal voting rights, where even an illiterate can cast a ballot, we do need term limits and maximum age.


lol straight outta idiocracy.
246   HeadSet   2020 Apr 8, 5:52pm  

I'm not even super tech savvy, but I'd doubt most 50 year olds could even set up a domain name

I remember going to Vandenburg AFB where I got to watch satellites being prepared prior to being set atop rockets. There was not a single guy working directly on those satellites that was under 60. Lots of intellect in the oldsters that do not go senile. And by the way, setting up a domain name is kind of a specialized task, even if not hard. How many 30 year olds do you think can set up a network using IPv6?
247   marcus   2020 Apr 8, 6:13pm  

:
Maximum age for starting a first term should be somewhere about 66 or 67. And even that old should be discouraged, it's a demanding job, that required boatloads of golf.
248   theoakman   2020 Apr 8, 6:47pm  

Shaman says
rd6B says
theoakman says
Cristina said she put her hubby on a diet of whole, organic meals, like chicken soup and dishes low in chemicals

I wonder how this idiot came to conclusion that chicken soup does not contain chemicals...water is a chemical, proteins are chemicals, and so on. Revoke er high school diploma.


Yah I made this argument a bunch of times after I got my BS in Chemistry... People never appreciated it. The titration is real.


I feel your pain. When I was a grad student in Chemistry, I sold hot sauce I made on the side at a farm. I grew all the peppers and fermented them myself. I literally had 4 ingredients. Peppers, vinegar, salt, xanthan gum. The product was a far superior texture with just a tiny pinch. Every granola fuck would question me adding a "chemical". I would literally explain to them the biological process that creates xanthan gum and they didn't listed because they didn't like the name. I would just tell them not to buy it because I sold out every day anyway. The best part was...once they realized I didn't need their business, then they would buy...the fucks.

Another time, I was in whole foods and this girl is looking at a bag of chips with her friend and says "I would never put a poison like maltodextrin in my body". She's covered from her neck down in fucking tattoos. What, ink in your skin for life is fine but anything you don't like the name of cannot pass through your digestive track?

That's the thing that really pisses me off with these people. They are always all inked up but so conscious of what they put into their body. They all smoke weed too (not that I'm against that but just have a set of values consistent with each other).

As far as homeopathic shit goes....all the females at my workplace run workshops where they claim if you spray lavender oil on god knows what....it cures everything! Oh you have allergies...try lavender oil. Oh you are depressed...try lavender oil. Oh you have a fever? Try lavender oil. Oh you have Wuhan Flu? Here...spray the lavender oil in your throat. I'm sure Chris Cuomo fucking reeks of lavender oil right now.

These are the same people probably badmouthing the potential of anti-virals....medications that literally are designed to interfere with viral replication!

ok end rant...
249   HeadSet   2020 Apr 8, 6:55pm  

When I was a grad student in Chemistry, I sold hot sauce I made on the side at a farm.
Every granola fuck would question me adding a "chemical".


Tell them the xanthan gum was only added to stop the pepper sauce from melting the bottle....
250   mell   2020 Apr 8, 6:55pm  

theoakman says
Shaman says
rd6B says
theoakman says
Cristina said she put her hubby on a diet of whole, organic meals, like chicken soup and dishes low in chemicals

I wonder how this idiot came to conclusion that chicken soup does not contain chemicals...water is a chemical, proteins are chemicals, and so on. Revoke er high school diploma.


Yah I made this argument a bunch of times after I got my BS in Chemistry... People never appreciated it. The titration is real.


I feel your pain. When I was a grad student in Chemistry, I sold hot sauce I made on the side at a farm. I grew all the peppers and fermented them myself. I literally had 4 ingredients. Peppers, vinegar, salt, xanthan gum. The product was a far superior texture with jus...


I don't take any advice from any chick that isn't A) very hot and B) not tattoed/pierced. Back in the days a lot of those trends and miracle cures where still fake fads but at least the chicks were hot. These days they're being sold by slobs. lol
251   Ceffer   2020 Apr 8, 6:59pm  

theoakman says
Another time, I was in whole foods and this girl is looking at a bag of chips with her friend and says "I would never put a poison like maltodextrin in my body". She's covered from her neck down in fucking tattoos. What, ink in your skin for life is fine but anything you don't like the name of cannot pass through your digestive track?

That's the thing that really pisses me off with these people. They are always all inked up but so conscious of what they put into their body. They all smoke weed too (not that I'm against that but just have a set of values consistent with each other).


Many have a much reduced pain threshold, too. I speculate they are in more or less a constant immune crisis because of all the ink in their skin provoking a response. I think these tatters are going to have a lot of autoimmune diseases and arthritoids as they age.
252   AD   2020 Apr 8, 7:06pm  

Patrick says


see https://twitter.com/MichaelCoudrey/status/1241354642417577986

Trump retweeted this.


Listening to Bloomberg Radio (station WBBR) and they have been interviewing family and urgent care medical doctors who have said the hydrox and antibiotic mix of Rx have been lifesavers with fighting coronavirus for their patients.

Seems like Bloomberg is not toeing the Democrat media (ie., CNN, NBC, Washington Post, etc.) line and is reporting about preliminary results from the Rx treatments.
253   MisdemeanorRebel   2020 Apr 8, 7:47pm  

theoakman says

That's the thing that really pisses me off with these people. They are always all inked up but so conscious of what they put into their body. They all smoke weed too (not that I'm against that but just have a set of values consistent with each other).

As far as homeopathic shit goes....all the females at my workplace run workshops where they claim if you spray lavender oil on god knows what....it cures everything! Oh you have allergies...try lavender oil. Oh you are depressed...try lavender oil. Oh you have a fever? Try lavender oil. Oh you have Wuhan Flu? Here...spray the lavender oil in your throat. I'm sure Chris Cuomo fucking reeks of lavender oil right now.


I hate when those dumbasses ask you if you've "researched?" or say "I've researched" which usually means they spent 15 minutes looking at Mama's Organics or the EarthCrunch website, never took HS Chemistry and have no fucking clue about jack shit.



Lavender Oil is also a penis buster. I forbade my wife from putting that on my kid to help him sleep.
https://www.nih.gov/news-events/news-releases/lavender-tea-tree-oils-may-cause-breast-growth-boys
254   Patrick   2020 Apr 9, 8:17am  

https://www.middleeasteye.net/news/coronavirus-turkey-hydroxychloroquine-malaria-treatment-progress

Turkey has made significant progress in treating coronavirus patients in the early stages of the disease with the controversial malaria drug hydroxychloroquine, Turkish officials have said. ...

“Many countries prescribe this drug to intubated patients,” Koca said. “However, our science board suggested that the drug is really beneficial in the early stages to prevent the spread of the virus in the body.”

The health minister reminded viewers that one of the fundamental features of the disease was lung infection.

“We believe beginning early treatment [with this drug] played a big role in reducing the rate of lung infection among the patients,” he said. ...

Many doctors argue that the drug has not been tested enough yet to be used to treat coronavirus patients.

However, earlier this month, doctors in China reported that hydroxychloroquine had helped to speed up the recovery of some patients who had mild symptoms.

Dramatic fall in pneumonia rates
The Turkish official told MEE that the drug was effective against pneumonia, which is seen as among the leading causes of death for coronavirus patients.

Most of the patients taken to intensive care or who are put on ventilators are there because they have developed pneumonia.

“The minister, instead of underlying the importance of the drug itself, has pointed out the benefit of using the drug in the early stages, before the patient becomes severely ill,” the official said.

Statistics released by the Turkish health ministry on Tuesday showed that since beginning the treatment, new cases of lung disease among coronavirus patients have greatly decreased.

On 24 March, 60 percent of coronavirus cases registered were patients with pneumonia, while on 6 April that had fallen to 19.5 percent.


255   Patrick   2020 Apr 9, 8:19am  

https://www.nytimes.com/2020/04/01/health/hydroxychloroquine-coronavirus-malaria.html

By Denise Grady
April 1, 2020

The malaria drug hydroxychloroquine helped to speed the recovery of a small number of patients who were mildly ill from the coronavirus, doctors in China reported this week.

Cough, fever and pneumonia went away faster, and the disease seemed less likely to turn severe in people who received hydroxychloroquine than in a comparison group not given the drug. The authors of the report said that the medication was promising, but that more research was needed to clarify how it might work in treating coronavirus disease and to determine the best way to use it.

“It’s going to send a ripple of excitement out through the treating community,” said Dr. William Schaffner, an infectious disease expert at Vanderbilt University.

The study was small and limited to patients who were mildly or moderately ill, not severe cases. Like many reports about the coronavirus, it was posted at medRxiv, an online server for medical articles, before undergoing peer review by other researchers.

But the findings strongly support earlier studies suggesting a role for the drug, Dr. Schaffner said.
256   Onvacation   2020 Apr 9, 8:23am  

WookieMan says
I'd doubt most 50 year olds could even set up a domain name and wordpress themed site without having to hire someone.

Most millenials couldn't figure out how to use a rotary phone; so what?
257   Onvacation   2020 Apr 9, 8:25am  

WookieMan says
. Term limits and old age limits would be a massive step in the right direction.

Or maybe some kind of a mental test? Maybe we should have them debate each other?
258   Patrick   2020 Apr 9, 6:30pm  



Question: Why would the PM of Israel thank India for chloroquine shipments if it were useless?

Answer: He wouldn't.

The Israelis know what they are doing, and they don't naively swallow bullshit from the media like most Americans do.

The mainstream US media sucks, especially the NY Times and NPR. They are only hate and propaganda 24/7. They make Fox News look good.
259   Bd6r   2020 Apr 9, 6:34pm  

Patrick says
They make Fox News look good.

which, by the way, is really difficult - Fox is scraping the bottom of barrel as well. But somehow CNNPC etc manage to outdo Fox...
260   marcus   2020 Apr 9, 11:03pm  

Patrick says
Question: Why would the PM of Israel thank India for chloroquine shipments if it were useless?


Because it's a part of one of the most promising experimental stacks of medications doctors are experimenting with throwing at this very frightening virus.
261   FuckTheMainstreamMedia   2020 Apr 9, 11:12pm  

marcus says
Patrick says
Question: Why would the PM of Israel thank India for chloroquine shipments if it were useless?


Because it's a part of one of the most promising experimental stacks of medications doctors are experimenting with throwing at this very frightening virus.


It’s not “very frightening”, or at least ought not be.


People are, however, quite hysterical. I wanna punch women that fear their kids will die from China virus in the baby maker. Their crotch goblins probably won’t get it, if they do get it they probably won’t get sick, and they certainly will not die.
262   marcus   2020 Apr 10, 12:22am  

:
"It’s not “very frightening”, or at least ought not be."

Perhaps not if you're only thinking of yourself, and you're not old. That's not what I meant.
263   WookieMan   2020 Apr 10, 7:19am  

marcus says
:
"It’s not “very frightening”, or at least ought not be."

Perhaps not if you're only thinking of yourself, and you're not old. That's not what I meant.

Can't the old think for themselves and just stay home? And the young avoid them? Is this really all that complicated? #NO
264   FuckTheMainstreamMedia   2020 Apr 10, 8:17am  

WookieMan says
marcus says
:
"It’s not “very frightening”, or at least ought not be."

Perhaps not if you're only thinking of yourself, and you're not old. That's not what I meant.

Can't the old think for themselves and just stay home? And the young avoid them? Is this really all that complicated? #NO


Correct. Old people and those with compromised health should stay the fuck at home.
265   Y   2020 Apr 10, 9:05am  

No they can't.

WookieMan says
Can't the old think for themselves
268   Patrick   2020 Apr 11, 8:50pm  

http://noisyroom.net/blog/2020/04/11/hydroxychloroquine-cocktails-how-many-anecdotes-does-it-take-to-change-a-light-bulb-dr-fauci/comment-page-1/

We have plenty of people around the world who have had to be admitted into hospitals, ICU’s, put on ventilators and died. We have a lot of information about the risk factors associated with age and underlying conditions. If a drug is anything more than just slightly effective, all we have to do is statistically compare the outcomes of people getting the drug to the outcomes we have seen based on age and underlying conditions.

That is what front line doctors are doing and they are reporting that there is clear and, sometimes, profound clinical improvement in many, many patients, especially when this combination of medicines is administered earlier rather than later. Some of these are highly respected, practicing infectious disease experts. And we’ve had decades of experience in prescribing these drugs so there is no uncertainty as to their safety.
269   marcus   2020 Apr 11, 9:27pm  

Patrick says
profound clinical improvement in many, many patients, especially when this combination of medicines is administered earlier rather than later.


But if it's ealrier, what pecentage would be getting better anyway ?

Patrick says
all we have to do is statistically compare the outcomes


Yeah, that's all. But if you understand statistics you know that say, if going with standard treatments, 5% die, One sample of 100 where 1 or 2 or 3 die or one sample of 100 where 7 or 8 die is not conclusive at all, in fact it would be somewhat expected. Certainly a doctor with 20 patients that are all treated early and get better, doesn't prove nearly as much as you might think it does.

But we're dealing with something closer to 2% of symptomatic people die. This means that about 40% of the time you do a sample of 100 your going to get 1 or less dying. That's with whatever standard treatments.

It would take a lot of double blind samples of 100 to start knowing if it works. But they think it might, so who wants to be in a control group ? They're just going to use it until they have something better. But don't expect news that it work great, unless we start to see the death rate dropping faster than the leading drop in new cases.

Actually that would be the best indicator if it's working. I think it's safe to assume a lot of doctors are using it.
270   Misc   2020 Apr 12, 2:49am  

So, who picks the people that are gonna be the test subjects that don't get the treatment?
272   MisdemeanorRebel   2020 Apr 12, 12:19pm  

The new NPR/CNN/NYT catchphrase for HCQ is "Unproven Drug".

LOL, the butthurt that the big Trump Killing Virus that would generate panic and billions in BigPharma profits, laid low by a $10 combination of two ancient generics
273   Patrick   2020 Apr 12, 4:11pm  

Is there somewhere we can get reliable statistics on the course of the disease in thousands of patients and what they were treated with at what stage?

It's insane to tell people who could die that they have to wait a year for a double-blind test with well-known drugs generally considered safe for mass use for decades now.

And it's unnecessary. We just need to analyze the existing statistics, if we can find them.
275   Tenpoundbass   2020 Apr 12, 6:26pm  

Liberals be all like glad that Fauci says a drug they know works based on the evidence of Doctor's testimonial they've seen. Because they don't want Trump to get credit for saving the world.

Same Liberal when he or his wife gets it, they'll go all Denzel Washington on the Emergency room lobby, until someone brought him some damn Trump Pills.
278   Shaman   2020 Apr 12, 6:29pm  

ThreeBays says
We know that at very best this drug will have a very mild effect on changing the course of the disease, if it has any effect at all. That's what the data shows so far. And not without adverse consequence. It's irresponsible to promote this drug at this time. Quack drug.


That’s your very uninformed and wrong opinion but I guess you’re entitled to it. I take note that you provided absolutely no justification for said crappy opinion.
Just naked TDS.

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