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Lipid nanoparticles for the inhalation of mRNA. Coming to a neighborhood near you.


               
2022 Dec 12, 7:43pm   356 views  7 comments

by Al_Sharpton_for_President   follow (6)  

It is now clear that messenger RNA (mRNA) encoding the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delivered by lipid nanoparticles (LNPs) triggers the efficient protection of lungs from infection by the virus.

Generally, mRNA therapeutics could also be used to treat or prevent cystic fibrosis, lung cancer, asthma and other lung diseases.

Lipid Nano Pariticles (LNPs) encapsulating mRNAs provide the nucleic acids with protection against degradation by ribonucleases, facilitate their uptake by cells, are largely non-immunogenic and allow for the controlled release of the encapsulated therapeutic.

The most direct route (and probably also the safer and most efficient) for administering LNP-encapsulated mRNAs to the lungs is via inhalation, as it maximises the concentration of the therapeutic in these organs and limits its systemic exposure.

Inhaled LNP encapsulated mRNA takes over the immune system, hijacking it to carry out the mRNA message.

Writing in Nature Biomedical Engineering, James Dahlman, Philip Santangelo and colleagues now describe a screening approach for the optimization of LNPs so that mRNA can be delivered to the lungs in the form of nebulized aerosols.

https://www.nature.com/articles/s41551-021-00794-x





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1   Patrick   2025 Sep 3, 3:05pm  

The lipid nanoparticles are poisonous in themselves, even without delivering mutant mRNA to create the poisonous spike protein:

https://transcriberb.dreamwidth.org/216972.html


DR. RICHARD URSO: I want to ask Dr. Malone that question. Because I've worked with lipid nanoparticles for chemotherapy. They are like garlic, they go everywhere. They can slip through a door crack, they go through very tight junctions. That's what they do. That's why when I first saw the technology I knew it was going to end up in the brain. Because that's one of the things they were doing, was trying to find lipid nanoparticles to carry chemotherapeutic agents—

SENATOR RON JOHNSON: I'm concerned about it getting into the brain.

DR. RICHARD URSO: Well, that was the actual original design for lipid nanoparticles, to be used in chemotherapy because in order to direct chemotherapy to the brain, it's very difficult. So they were going to use lipid nanoparticles to do it. The problem was the lipid nanoparticles went into ovaries, bone marrow, adrenal glands, and other tissues. So it's still being worked on, studies are still being done.

But I was going to ask Dr. Malone, because Dr. McCullough had just talked about the fact that he has concerns. Do you have concerns for this vaccine in children, knowing that it's going into the brain, the bone marrow, the adrenals, and all these other organs?

DR. ROBERT MALONE: So the answer's yes. I've said that repeatedly. I've put out a 4 minute clip in which I talk about the damage and risk to children in brain, heart, coagulopathy, reproductive systems, and immune systems. That resulted in direct attack from the Israeli Ministry of Health on my personal reputation, multiple factcheckers denying it. But the data are incontrovertible.

But to your point, Richard, and Jill[1] and I can attest, you know, I do have some credibility here because I did create this technology. ...

SENATOR RON JOHNSON: But, but but you don't work for the CDC, NIH, and FDA?[3]

DR. ROBERT MALONE: No. No, I actually work for the DOD [Department of Defense] from time to time. So I do know about the untranslated regions, why they're there. I do understand explicitly, in detail, about reverse transcriptase and what it can do, etcetera.

But I can tell you that we moved off of trying to develop further these mRNA and DNA complexes based on on our work in nonhuman primates and in mice. We spent years with both commercial funding and various public funding, not NIH, trying to advance this technology. Many, many different cationic lipid formulations, compounds tested, screened for toxicity. We could never overcome the hyper-inflammatory characteristics of these polynucleotide cationic lipid complexes. We could never get there.

Now the Karikó and Weissman assertion, and it's, you know, it's like baseball.[4] I brought Kitty [Katalin] Korikó into this like a decade after I'd made the basic discoveries. They assert the insertion of the pseudoridine reduces the inflammatory response.[5] But the data show that that is a marginal decrease, and the data also show, from their competitor, it's important to remember that they are they are BioNTech,[6] Katy's a vice president. So their competitor in Germany has shown very good immune response without the pseudouridine.

So you're right, pseudouridine is a [inaudible] compound, the logic is, incorporation of pseudouridine reduces the inflammatory response, but the inflammatory response is still there.

And to your point, Richard, we are clearly seeing not only specific effects associated with spike protein, but nonspecific affects associated with lipo-nano complexes.

How do we know that? Because Moderna gave us a presentation to their stockholders recently where they rolled out their Phase I data on their influenza vaccine candidates that are using the same technology platform. So no spike protein associated influenza antigens and in their hands its 100 microgram dose, which is the dose that's used in the Emergency Use Authorized vaccines. 90% of the subjects had adverse events compared to 30% in the placebo group. This is Phase I data.

Now that data has not been disclosed publicly, it was only disclosed to their stockholders. But what it clearly demonstrates is that the cationic lipid RNA complexes have intrinsic toxicity above and beyond that just that associated with the spike.

So when we get into these arguments about is it spike, is it the lipids, buh buh buh, it's both, OK. We have a tendency to get binary, it's this or that. No, it can both.

Regarding the data package from Japan that Byram Bridle[7] first acquired, and then I would think I was the first after that. People often get confused about this, but Senator, this is thing that worries me the most, is that that limited data that was not produced to any quality standard that any clinical trial, you know, precursor nonclinical data package I've ever seen would be allowed to be used. What the FDA and the regulatory authorities all over the world allowed was for Pfizer to collect data involving unrelated RNAs, other candidates amalgamated together and submitted as a package. And in those data, which were not according to good laboratory practices, they did demonstrate that these lipid nanoparticles go all over the body, just as Richard is saying, and that oddly they seem to differentially go to ovaries and bone marrow, but ovaries relative to testes.

And it's important everybody kind of latches onto this and they say, oh, there's spike protein in the ovaries. No, that's not what they measured. They didn't ever measure spike protein. What they measured was the lipid component, the synthetic lipids, which is the other thing you didn't mention in this cocktail. OK? These synthetic lipids go to ovaries.

Now, who cares? Well, when your child is born, when your daughter is born, she has all the eggs she's ever going to have in her ovaries. And we do know that, and the CDC now finally acknowledges after women all over the world complaining about their altered menses and getting— I mean, it was, I felt like I was in the mid-20th century. It was attributed to hysteria, much as your own story, these alterations in menstruation were, were, were believed to represent hysterical women. The CDC is now acknowledging it.

The thing is that the ovary drives menstruation. As Brian will, I'm sure attest. Hormonally the ovary drive menstruation. When we're seeing altered menstrual cycles, we're seeing the phenomena of post-menopausal women starting to bleed. That's a hallmark that something's going on in the ovaries. And we know that these lipids are going to the ovaries. We know that these are synthetic, abnormal fats that insert into membranes and change the charge of cell surfaces. That's all true.

So all we have is this trail of breadcrumbs. And unfortunately, apparently, the FDA made a determination that they would treat these products using their standard checklist approach for a standard vaccine, and they did not use the checklist that they would use for gene therapy. And furthermore, they didn't make any special accommodation for the novel nature of this technology, which has not been previously characterized.

And so what we end up with is the FDA making a decision to move forward with a data package that's grossly inadequate, that doesn't meet any standards at all that are the norms in my industry that I've been trained on, and that is overlooking known problems, and then when patients are coming, women in particular in complaining about these reproductive effects, they're being subjected to the same kind of character assassination and ridicule that we all get routinely from our friends Mark Zuckerberg, et al.[8]

So, Senator, I do, in terms of the pediatric, as somebody who is intimately familiar with this technology, I'm not too worried about the untranslated regions but that's a formal possibility and it absolutely should have been investigated, and the FDA has been grossly derelict in not following through on these things.

But beyond that, we have a clear trail of breadcrumbs about reproductive toxicity that's not being followed up. And I am concerned about our children. I'm concerned about all of those effects, brain, heart, blood coagulation, reproductive system, immunologic system. And furthermore, they're not at risk for this virus! Why are we doing this in, in mandating these vaccines for children? Just breaks my heart.
2   Ceffer   2025 Sep 3, 4:02pm  

My wife and I think our vaxxed neighbors shed. We had our block party Labor Day get together in tri valley, and we both afterward felt coughing and lung congestion afterward. We have experienced it before when gathering with them, but fortunately it lasts for a day or two and clears up, and isn't serious. Several of them were fucked by vaccines, but no fatalities yet as in Santa Cruz, though one neighbor dying of bowel cancer in tri valley.
3   stereotomy   2025 Sep 7, 2:33pm  

Ceffer says

My wife and I think our vaxxed neighbors shed. We had our block party Labor Day get together in tri valley, and we both afterward felt coughing and lung congestion afterward. We have experienced it before when gathering with them, but fortunately it lasts for a day or two and clears up, and isn't serious. Several of them were fucked by vaccines, but no fatalities yet as in Santa Cruz, though one neighbor dying of bowel cancer in tri valley.

I've experienced the same. Nowadays, before going to any mass gathering, I take a prophylactic dose (0.2 mg/Kg) of Ivermectin in addition to at least 100 mg zinc and 500 Mg quercetin phytosome. That usually nips any shedding symptoms in the bud.

FYI - Alldaychemist is your friend for ivermectin at $1 per 12 mg tablet, unless you can get legit sourcing for around that price.
4   Ceffer   2025 Sep 7, 2:44pm  

stereotomy says

FYI - Alldaychemist is your friend for ivermectin at $1 per 12 mg tablet, unless you can get legit sourcing for around that price.

We just use the horsey stuff in a tube, squeeze out a bit at a time with Quercetin tablets. I remember when Amazon stopped stocking the horsey tubes at the behest of the Democide guardians.
5   HeadSet   2025 Sep 7, 2:47pm  

Ceffer says

We just use the horsey stuff in a tube

I hope you are referring to "horse paste" ivermectin and not some Tim Walz imitation.
6   stereotomy   2025 Sep 8, 3:55am  

Ceffer says

stereotomy says


FYI - Alldaychemist is your friend for ivermectin at $1 per 12 mg tablet, unless you can get legit sourcing for around that price.

We just use the horsey stuff in a tube, squeeze out a bit at a time with Quercetin tablets. I remember when Amazon stopped stocking the horsey tubes at the behest of the Democide guardians.

I have 2 tubes in "Apple Flavor." That stuff is also good for dermal application (warts, etc.) and makes you smell like an orchard. Tractor supply for the win.
7   Ceffer   2025 Sep 15, 4:40pm  

They're going to get the depopulation toxins into you one way or another.

https://t.me/tribunalsandexecutions/527449

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