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The spike protein induces cancer by creating a tumor-promoting microenvironment. The authors note, unsurprisingly, that tumors induced by the spike protein are


               
2025 Dec 22, 5:39am   58 views  6 comments

by HANrongli   follow (0)  




Wallace, et al. Provide Ample Evidence Supporting My Hypothesis that the Spike Protein Induces Cancer by Creating a Tumorigenic Microenvironment
Not surprisingly, the authors note that tumors induced by the Spike Protein are aggressive.
WALTER M CHESNUT
DEC 22

Wallace 等人提供了充分证据,支持我的假设:刺突蛋白通过创造促肿瘤微环境而诱发癌症。作者并不意外地指出,由刺突蛋白诱导的肿瘤具有高度侵袭性。

沃尔特·M·切斯纳特(Walter M. Chesnut)
12 月 22 日

https://open.substack.com/pub/wmcresearch/p/wallace-et-al-provide-ample-evidence

Intratracheal delivery of SARS-CoV-2 Spike protein (SP) increases lung cancer incidence.

A. Schematic illustration of the urethane-induced lung cancer model. B. Representative gross images of lung cancer. C. SP-enhanced lung tumor incidence in K18-hACE2TG (hACE2TG) mice receiving SP or P3.1 control lysate. D. Comparison of SP-enhanced lung tumor incidence between K18-hACE2TG (hACE2TG) and K18-hACE2TG/Tymp-/-(hACE2TG/Tymp-/-) mice. E & F. Hematoxylin & Eosin staining with representative histological images of lung tumors. G & H. Immunohistochemical staining for p40, a marker of lung squamous cell carcinoma. Brown staining indicates p40-positive cells.

It was about four years ago that I wrote an article summarizing how I believed the Spike Protein would induce multiple microtumors by creating the perfect tumorigenic microenvironment.

It is one thing to plant a seed. It is another for it to grow successfully. It must have the right environment – and tumors must have the right microenvironment.

It has been established that the Spike Protein of SARS-CoV-2 impairs DNA Damage repair while simultaneously downregulating tumor suppressor proteins p53 and BRCA.

This is the “planting the seed” part of establishing micrometastatic disease without a primary tumor.

For those who are not familiar, most cancer patients die of METASTASIS. This is when their tumor spreads to other parts of the body and is almost universally initially undetectable. This is referred to as “occult metastasis.”

But, what would happen if you generated occult metastases WITHOUT having the initial tumor present?

You would indeed have an immense number of oncogenic “black holes” roaming your body. But, as I mentioned earlier, it is one thing to plant a seed. It is another to ensure that it grows. After all, most acorns do not produce an oak tree.

You need what is known as a “Tumor Microenvironment” for these “tumorlings” to grow into tumors. And, what is paramount in a successful tumor microenvironment? THE TRANSFORMATION OF THE MICROVASCULAR SYSTEM TO PROMOTE MULTISTAGE TUMORIGENESIS.

Expression of SARS-CoV-2 antigens (including the Spike Protein) triggered an altered secretory pattern leading to a pro-inflammatory and pro-angiogenic microenvironment.

MIRACLE-GRO FOR TUMORS
https://wmcresearch.org/miracle-gro-for-tumors/

I created a satiric, illustrative image for this phenomenon which many readers have seen elsewhere. For example, Jeff Rense’s site used it.

Now, we have actual evidence that this is indeed occurring. It is in the manner in which I predicted – pro-inflammatory, pro-angiogenic.

In this study, we provide convergent human and experimental evidence that SARS-CoV-2 infection increases the risk of lung cancer and identify TYMP as a previously unrecognized molecular driver of Spike Protein (SP)–induced lung injury, fibrosis, and tumorigenesis. By integrating large-scale clinical data with mechanistic mouse models, we demonstrate that TYMP amplifies SP-triggered inflammation and fibrotic remodeling, facilitates STAT3 expression, and shapes a tumor-permissive immune microenvironment. These findings establish TYMP as a central pathogenic mediator linking SARS-CoV-2 respiratory injury to increased lung cancer risk.

Using a urethane-induced lung cancer model, we found that prior SP exposure significantly increased tumor incidence and aggressiveness.

Thymidine Phosphorylase Drives SARS-CoV-2 Spike Protein-Induced Lung Tumorigenesis
https://www.biorxiv.org/content/10.64898/2025.12.14.694192v1.full

The driving force they identify, Thymidine Phosphorylase (TP), is something which is actually induced in the tumor microenvironment, suggesting we may have a chicken/egg situation here. Does the Spike Increase TP? Does TP enhance the Spike’s oncogenic abilities? Is there a mutual dynamic? As I just stated, TP is often INDUCED in the tumor microenvironment.

Thymidine phosphorylase (TP) is often induced in the tumour microenvironment by physiological and chemical stress. Its induction protects cells from apoptosis and helps cell survival by stimulating nucleoside metabolism and angiogenesis.

Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment
https://pubmed.ncbi.nlm.nih.gov/15737832/

I agree with the authors that TYMP should be investigated as a potential avenue for therapeutic intervention, and perhaps prevention regarding Spike Protein induced cancers.

In conclusion, this study reveals TYMP as a key molecular nexus through which SARS-CoV-2 SP promotes lung injury, fibrosis, and cancer development. By identifying TYMP as both a biomarker and effector of SP-induced pathology, our findings open new avenues for therapeutic intervention and highlight the urgent need for cancer risk assessment in individuals recovering from COVID-19.

Thymidine Phosphorylase Drives SARS-CoV-2 Spike Protein-Induced Lung Tumorigenesis
https://www.biorxiv.org/content/10.64898/2025.12.14.694192v1.full

I am also quite certain that this mechanism applies to other cancers the Spike Protein may induce. This gives us more concrete evidence that the newly described “turbo-cancers” are real and are almost certainly caused by the Spike Protein of SARS-CoV-2. I will continue to search for mechanisms of this pathological protein, and ways to mitigate/prevent the damage.

I did not send out a Giving Tuesday message as that was prime time for finding gifts for family and friends. If you wish to give a last-minute gift to this independent researcher, it would be immensely appreciated. Please consider becoming a paid subscriber, donating via the PayPal link below, or contacting me for crypto addresses, should you wish to donate crypto. I will be taking my annual end of year break from writing, returning with New Year’s Hope on New Year’s Day and then resuming regular postings on January 4th.

Please have blessed, hopeful, healthy and happy holidays! Thank you for another year of discovery and hope.

Intratracheal delivery of SARS-CoV-2 Spike protein (SP) increases lung cancer incidence.

A. Schematic illustration of the urethane-induced lung cancer model. B. Representative gross images of lung cancer. C. SP-enhanced lung tumor incidence in K18-hACE2TG (hACE2TG) mice receiving SP or P3.1 control lysate. D. Comparison of SP-enhanced lung tumor incidence between K18-hACE2TG (hACE2TG) and K18-hACE2TG/Tymp-/-(hACE2TG/Tymp-/-) mice. E & F. Hematoxylin & Eosin staining with representative histological images of lung tumors. G & H. Immunohistochemical staining for p40, a marker of lung squamous cell carcinoma. Brown staining indicates p40-positive cells.

It was about four years ago that I wrote an article summarizing how I believed the Spike Protein would induce multiple microtumors by creating the perfect tumorigenic microenvironment.

It is one thing to plant a seed. It is another for it to grow successfully. It must have the right environment – and tumors must have the right microenvironment.

It has been established that the Spike Protein of SARS-CoV-2 impairs DNA Damage repair while simultaneously downregulating tumor suppressor proteins p53 and BRCA.

This is the “planting the seed” part of establishing micrometastatic disease without a primary tumor.

For those who are not familiar, most cancer patients die of METASTASIS. This is when their tumor spreads to other parts of the body and is almost universally initially undetectable. This is referred to as “occult metastasis.”

But, what would happen if you generated occult metastases WITHOUT having the initial tumor present?

You would indeed have an immense number of oncogenic “black holes” roaming your body. But, as I mentioned earlier, it is one thing to plant a seed. It is another to ensure that it grows. After all, most acorns do not produce an oak tree.

You need what is known as a “Tumor Microenvironment” for these “tumorlings” to grow into tumors. And, what is paramount in a successful tumor microenvironment? THE TRANSFORMATION OF THE MICROVASCULAR SYSTEM TO PROMOTE MULTISTAGE TUMORIGENESIS.

Expression of SARS-CoV-2 antigens (including the Spike Protein) triggered an altered secretory pattern leading to a pro-inflammatory and pro-angiogenic microenvironment.

MIRACLE-GRO FOR TUMORS
https://wmcresearch.org/miracle-gro-for-tumors/

I created a satiric, illustrative image for this phenomenon which many readers have seen elsewhere. For example, Jeff Rense’s site used it.

Now, we have actual evidence that this is indeed occurring. It is in the manner in which I predicted – pro-inflammatory, pro-angiogenic.

In this study, we provide convergent human and experimental evidence that SARS-CoV-2 infection increases the risk of lung cancer and identify TYMP as a previously unrecognized molecular driver of Spike Protein (SP)–induced lung injury, fibrosis, and tumorigenesis. By integrating large-scale clinical data with mechanistic mouse models, we demonstrate that TYMP amplifies SP-triggered inflammation and fibrotic remodeling, facilitates STAT3 expression, and shapes a tumor-permissive immune microenvironment. These findings establish TYMP as a central pathogenic mediator linking SARS-CoV-2 respiratory injury to increased lung cancer risk.

Using a urethane-induced lung cancer model, we found that prior SP exposure significantly increased tumor incidence and aggressiveness.

Thymidine Phosphorylase Drives SARS-CoV-2 Spike Protein-Induced Lung Tumorigenesis
https://www.biorxiv.org/content/10.64898/2025.12.14.694192v1.full

The driving force they identify, Thymidine Phosphorylase (TP), is something which is actually induced in the tumor microenvironment, suggesting we may have a chicken/egg situation here. Does the Spike Increase TP? Does TP enhance the Spike’s oncogenic abilities? Is there a mutual dynamic? As I just stated, TP is often INDUCED in the tumor microenvironment.

Thymidine phosphorylase (TP) is often induced in the tumour microenvironment by physiological and chemical stress. Its induction protects cells from apoptosis and helps cell survival by stimulating nucleoside metabolism and angiogenesis.

Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment
https://pubmed.ncbi.nlm.nih.gov/15737832/

I agree with the authors that TYMP should be investigated as a potential avenue for therapeutic intervention, and perhaps prevention regarding Spike Protein induced cancers.

In conclusion, this study reveals TYMP as a key molecular nexus through which SARS-CoV-2 SP promotes lung injury, fibrosis, and cancer development. By identifying TYMP as both a biomarker and effector of SP-induced pathology, our findings open new avenues for therapeutic intervention and highlight the urgent need for cancer risk assessment in individuals recovering from COVID-19.

Thymidine Phosphorylase Drives SARS-CoV-2 Spike Protein-Induced Lung Tumorigenesis
https://www.biorxiv.org/content/10.64898/2025.12.14.694192v1.full

I am also quite certain that this mechanism applies to other cancers the Spike Protein may induce. This gives us more concrete evidence that the newly described “turbo-cancers” are real and are almost certainly caused by the Spike Protein of SARS-CoV-2. I will continue to search for mechanisms of this pathological protein, and ways to mitigate/prevent the damage.

I did not send out a Giving Tuesday message as that was prime time for finding gifts for family and friends. If you wish to give a last-minute gift to this independent researcher, it would be immensely appreciated. Please consider becoming a paid subscriber, donating via the PayPal link below, or contacting me for crypto addresses, should you wish to donate crypto. I will be taking my annual end of year break from writing, returning with New Year’s Hope on New Year’s Day and then resuming regular postings on January 4th.

Please have blessed, hopeful, healthy and happy holidays! Thank you for another year of discovery and hope. SARS-COV-2穗蛋白(SP)的肿瘤内递送增加了肺癌发病率。 A.氨基甲酸酯诱导的肺癌模型的示意图。 B.肺癌的代表性粗略图像。 C. SP-增强肺肿瘤发病率K18-Hace2Tg(HECE2TG)小鼠接受SP或P3.1对照裂解物。 D.在K18-Heace2Tg(Hace2Tg)和K18-Hace2Tg / Tymp - / - / - (Hace2Tg / Tymp - / - / - / - )小鼠中的Sp增强肺肿瘤发病率的比较。 E&F.血毒素与肺肿瘤代表组织学图像染色。 G&H.P40的免疫组化染色,肺鳞状细胞癌的标志物。 棕色染色表明p40阳性细胞。 这是大约四年前,我写了一篇关于我认为穗蛋白的刺激蛋白质如何通过产生完美的致瘤微环境来引起多种微观蛋白的文章。 种子是种子的一件事。 它是另一种成功的成功增长。 它必须具有正确的环境 - 并且肿瘤必须具有正确的微环境。 已经确定SARS-COV-2的尖峰蛋白损害DNA损伤修复,同时下调肿瘤抑制蛋白P53和BRCA。 这是“种植种子”,其部分建立微转移疾病而没有原发性肿瘤。 对于那些不熟悉的人,大多数癌症患者死于转移。 这是当他们的肿瘤蔓延到身体的其他部位时,几乎普遍初步最初无法察觉。 这被称为“隐匿性转移” 但是,如果你在没有初始肿瘤存在的情况下生成神经转移会发生什么? 你确实有一个巨大的致癌“黑洞”漫游你的身体。 但是,正如我之前提到的那样,种植种子是一件事。 它是另一种确保它的增长。 毕竟,大多数橡子都不会产生橡树。 您需要所谓的“肿瘤微环境”,用于这些“肿瘤”以生长为肿瘤。 而且,在成功的肿瘤微环境中是至关重要的? 微血管系统的转化促进多级肿瘤瘤。 SARS-COV-2抗原(包括尖峰蛋白)的表达引发了导致促炎和促血管生成微环境的改变的分泌模式。 用于肿瘤的Miracle-gro https://wmcresearch.org/miracle-gro-for-tumors/我创建了许多读者在其他地方看到的这种现象的讽刺的说明性形象。 例如,Jeff Rense的网站使用它。 现在,我们有实际证据确实发生。 它是我预测的方式 - 促炎,促血管生成。 在这项研究中,我们提供的会聚人和实验证据,即SARS-COV-2感染增加肺癌的风险,并将TYMP作为穗蛋白(SP)引起的肺损伤,纤维化和肿瘤引发的先前未被识别的分子驱动器。 通过将大规模的临床数据与机械小鼠模型集成,我们证明了TMP放大了SP触发的炎症和纤维化重塑,促进了STAT3表达,并形成了肿瘤允许免疫微环境。 这些研究结果建立了TMP作为将SARS-COV-2呼吸损伤联系起来增加肺癌风险的中央致病介质。 使用氨基甲酸酯诱导的肺癌模型,我们发现先前的SP暴露显着提高了肿瘤发病率和侵略性。 胸苷磷酸化酶驱动SARS-COV-2穗蛋白诱导的肺肿瘤肿瘤HTTPS://www.biorxiv.org/2025.12.14.694192V 飙升是否增加了tp? TP是否增强了穗的致力学能力? 有一个相互动感吗? 正如我刚刚所述的那样,TP通常在肿瘤微环境中诱导。 胸苷磷酸化酶(TP)通常通过生理和化学胁迫在肿瘤微环境中诱导。 其感应保护细胞免受凋亡的影响,通过刺激核苷代谢和血管生成来帮助细胞存活。 癌生物学和治疗中胸苷磷酸化酶(血小板衍生的内皮细胞生长因子)https://pubmed.ncbi.nlm.nih.gov/15737832/“我同意TYM的作者 总之,本研究揭示了TYMP作为关键分子Nexus,SARS-COV-2 SP促进肺损伤,纤维化和癌症发育。 通过鉴定TMP作为SP诱导病理学的生物标志物和效应,我们的调查结果开辟了新的途径,用于治疗干预,并突出迫切需要从Covid-19恢复的个人中的癌症风险评估。 胸苷磷酸化酶驱动SARS-COV-2穗蛋白诱导的肺肿瘤肿瘤HTTPS://www.biorxiv.org/2025.12.14.694192V 这给了我们更具体的证据表明新描述的“涡轮癌”是真实的,几乎肯定是由SARS-COV-2的尖峰蛋白引起的。 我将继续寻找该病理蛋白质的机制,以及减轻/防止损害的方法。 我没有发出周二的消息,因为这是寻找家人和朋友礼物的主要时间。 如果您希望向该独立研究员提供最后一分钟的礼物,则会非常感谢。 请考虑成为一名有偿订户,通过下面的PayPal链接捐赠,或者您是否希望捐赠Crypto,您可以联系我的加密地址。 我将在一年年底休息一下,从写作,在新的一年的日子里回归新年的希望,然后在1月4日恢复正常的帖子。 请祝福,充满希望,健康,节日快乐! 谢谢另一年的发现和希望。

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1   HANrongli   2025 Dec 22, 5:47am  



Jimmy Dore on the Covid narrative: "What woke me up was that I got vaccine injured."

"I was like, well, if they're lying about this, what else are they lying about? And it turns out... they were lying about everything."

"They lied about masks, they lied about herd immunity, they lied about natural immunity, they lied about lockdowns... There wasn't a thing they didn't lie about."

"And still people don't realise that they were lied to on such a grand scale, because I think it was such a big lie that they can't wrap their minds around it."

"And if people admit that they were lied to as much as they were... then they don't have to admit to themselves that they also acted like monsters."

"So instead... they just ignore it and go, oh, Covid's over, and so they don't have to face it."

吉米·多尔 (Jimmy Dore) 谈到新冠疫情的叙述时表示:“让我醒悟的是我因为疫苗受伤了。”

“我当时想,好吧,如果他们在这件事上撒了谎,那么他们还在撒谎什么?事实证明……他们在所有事情上都撒了谎。”

“他们在口罩问题上撒谎,在群体免疫力问题上撒谎,在自然免疫力问题上撒谎,在封锁问题上撒谎……他们没有什么不撒谎的。”

“但人们仍然没有意识到他们被欺骗了如此大规模,因为我认为这是一个很大的谎言,他们无法接受。”

“如果人们承认自己被欺骗了……那么他们就不必承认自己的行为也像怪物一样。”

“所以相反……他们只是忽略它,然后说,哦,新冠病毒已经结束了,所以他们不必面对它。”
2   HANrongli   2025 Dec 22, 7:21am  



Will you be giving your dog the new self-amplifying RNA rabies vaccine?

Dr. Sherri Tenpenny: "Our homeopathic vet... said the problem with it is all the side effects are exactly what you would see in a dog that has rabies."

"They've gone from tepid and mild to aggressive, to biting, to salivating, to angry, and all the different things that happen with rabies."

"And I said, well, if that's an SA-RNA vaccine, that means it will continue to replicate and make the imprint of rabies."

"I mean, if your dog licks you... is rabies going to be spread to humans? He said, nobody knows." 您会给您的狗注射新型自扩增 RNA 狂犬病疫苗吗?

Sherri Tenpenny 博士:“我们的顺势疗法兽医……说问题是它的所有副作用都与患有狂犬病的狗一样。”

“它们从不温不火、温和到具有攻击性、咬人、流口水、愤怒,以及狂犬病所发生的所有不同情况。”

“我说,好吧,如果这是一种 SA-RNA 疫苗,那就意味着它将继续复制并留下狂犬病的印记。”

“我的意思是,如果你的狗舔你……狂犬病会传播给人类吗?他说,没有人知道。” https://substack.com/@stopthoseshots/note/c-190498759
3   HANrongli   2025 Dec 22, 7:23am  




Stay away from Vaccines and Flu shots 远离疫苗和流感疫苗 https://substack.com/@ggtvstreams/note/c-190222174
4   HANrongli   2025 Dec 22, 7:25am  



‘During COVID the government paid scientists to create glioblastomas in mice then paid them to inject Nicotine to dissolve them. And it worked’.

Is this why they’re about to ban all Nicotine products ? “在新冠疫情期间,政府付钱给科学家在老鼠身上制造胶质母细胞瘤,然后付钱给他们注射尼古丁来溶解它们。 它奏效了”。

这就是他们要禁止所有尼古丁产品的原因吗? https://substack.com/@phrygiofphrygia/note/c-190343448
5   HANrongli   2025 Dec 22, 7:35am  



Ex-Pfizer chief scientific officer Dr. Mike Yeadon:

"The design of these molecular structures in the vaccines... has no other purpose but to injure and kill."

"The purpose of the pandemic... was to damage the economy, to get us used to doing what we're told under a mock emergency, and to roll up our sleeves to receive these dangerous materials."

"Some self-appointed group of very rich people have decided they don't like 8 billion people being on the planet, and want it to be a much smaller number." 前辉瑞首席科学官 Mike Yeadon 博士:

“疫苗中这些分子结构的设计……除了伤害和杀人之外没有其他目的。”

“这场大流行的目的……是为了损害经济,让我们习惯在模拟紧急情况下做我们被告知的事情,并卷起袖子接收这些危险材料。”

“一些自封的非常富有的人已经决定他们不喜欢地球上有 80 亿人,并希望这个数字少得多。” https://substack.com/@stopthoseshots/note/c-190496698
6   HANrongli   2025 Dec 22, 11:04am  






Dr. Mary Talley Bowden: "When you look at people that did not get the shots, [spike protein antibody levels are] typically under a thousand."

"People that have gotten these shots—they're ten times that, and this is four years later."

"It does not make sense because typically the antibody levels will just drop down over time, especially four years later."

"The test goes up to 25,000, and I have a lot of patients that exceed the upper limit of the test."

"So that is concerning." Mary Talley Bowden 博士:“当你观察那些没有接受注射的人时,[尖峰蛋白抗体水平]通常低于 1000。”

“接种这些疫苗的人是这个数字的十倍,而这是四年后的事了。”

“这没有意义,因为通常抗体水平会随着时间的推移而下降,尤其是四年后。”

“检测人数高达25000人,我有很多患者都超过了检测上限。”

“所以这令人担忧。” https://substack.com/@stopthoseshots/note/c-190498038

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