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Efficacy of hydroxychloroquine against Wuhan virus


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2020 Mar 21, 10:47am   12,688 views  290 comments

by Patrick   ➕follow (61)   💰tip   ignore  

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171   Bd6r   2020 Apr 1, 2:16pm  

and on a side note -
I have philosophical disagreements with trump with respect to fucking bailouts, but he has been such a paragon of intelligence relative to our media and libruls that I fail to see how his approval would not skyrocket when this is all over (unless economy collapses). He closed China border among librul screeching, he told people not to panic, now he is right about HCQ...being right over and over again, and media plants a minefield and then walks all over it themselves blowing their minuscule credibility leftovers to smithereens.
WookieMan says
You know they're just going to say Trump ordered the FDA to do/say this.

You're right, but fed bureaucracy does not work like that. They will not stick their necks out unless they are 120% sure about being right.
172   Rin   2020 Apr 1, 2:34pm  

WookieMan says
FOREVAH


Is that a Boston or a NY accent?

I think it's FOEVAH in Boston.
173   Heraclitusstudent   2020 Apr 1, 3:33pm  

Onvacation says
Do you really think all of the Trump's supporters blindly love him like Obama's did?

That's EXACTLY what the trumpsters are all doing in this thread.
174   socal2   2020 Apr 1, 3:45pm  

Heraclitusstudent says
That's EXACTLY what the trumpsters are all doing in this thread.


Because you all are putting up lame chicken-shit complaints and trying to polarize our country in a time of crisis.

- "He said he hoped the country would be open by Easter!"
- "He is hopeful and talking up hydroxchloroquine!"
- "He said Wuhan Virus!!!"

Of course Trumpers are going to circle the wagons over stupid complaints.

Besides, as of right now - the US is doing better than virtually every single modern Western European country in terms of deaths per capita - despite having a high population of obese and diabetic citizens and tens of thousands of Chinese flying into the country every single day up until Feb 1.
175   Heraclitusstudent   2020 Apr 1, 4:46pm  

That's all the fault of the infidels.
176   Onvacation   2020 Apr 1, 5:02pm  

Heraclitusstudent says
That's all the fault of the infidels.

You finally get it!
177   rdm   2020 Apr 1, 5:06pm  

socal2 says
Biden admits that travel bans would slow the spread, but he would not enact a ban because he would piss off his benefactors in China or put a stigma on Chinese Americans


Where does Biden say he wouldn't have enacted the travel ban(s)? Just make shit up, so we do just like the "media" one so complains about? That's the Trump play book

.socal2 says
An Op-Ed from Biden that spreads the lie that Trump disbanded the Pandemic team and cut the FDA and CDC?


Apparently reading comprehension is a problem too, don't know the difference between cut and proposed cuts? Which Trump absolutely did.

"He proposed draconian cuts to the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC) and the Agency for International Development — the very agencies we need to fight this outbreak and prevent future ones."
178   MisdemeanorRebel   2020 Apr 1, 5:16pm  

The most important chart. "IF ONLY WE HAD A NATIONAL HEALTH SERVICE!"

179   Bd6r   2020 Apr 1, 5:56pm  

Rin says
Is that a Boston or a NY accent?

I think it's FOEVAH in Boston.

German English
182   joshuatrio   2020 Apr 3, 6:09am  

BOOM!!!! Here you go @patrick:

https://www.citizenfreepress.com/breaking/laura-ingraham-bombshell-infectious-disease-md-reveals-results-of-hcq-trials/

Looks like we got a fix! How soon before they roll this out and the media stops hiding it?
183   theoakman   2020 Apr 3, 6:48am  

rdm says
Biden
rdm says
Where does Biden say he wouldn't have enacted the travel ban(s)? Just make shit up, so we do just like the "media" one so complains about? That's the Trump play boo


"We have, right now, a crisis with the coronavirus,” Biden said in Iowa Friday. “This is no time for Donald Trump’s record of hysteria and xenophobia – hysterical xenophobia – and fearmongering to lead the way instead of science"


That's clearly the words of someone who would have supported a travel ban from China. Dems were against it from the get go, and they used the WHO statements as their justification. After the Europe travel ban, the EU was against it, as were the Dems. Sorry...the left was late to the party and probably would have cost more lives initially. That's a fact. Trump should have shut the borders Jan 1st...unfortunately, the information just wasn't out there to justify that at the time. No country was fast enough to stop the entry and spread...none...it caught everyone by surprise. But the right actions were taken and initially fought by some.
184   Patrick   2020 Apr 3, 7:51am  

Patrick says


from https://public-cdn.sermo.com/covid19/c8/be4e/4edbd4/dbd4ba4ac5a3b3d9a479f99cc5/wave-i-sermo-covid-19-global-analysis-final.pdf


That same report shows Span and Italy have the highest use of hydroxychloroquine, at about 75% of doctors using it, which may help explain why their graphs of deaths are now flat.

The US has only 25% of doctors using it, and our death rate is still rising.

The hate for Trump is literally costing innocent lives. #TrumpPills
186   RWSGFY   2020 Apr 3, 5:22pm  

ThreeBays says
Welp, France might have done something to include more deaths in their statistics.



Ahh here's the reason.

On April 2, France reported 884 additional deaths that have occurred in nursing homes over the past days and weeks


#fuckingmorons
187   Patrick   2020 Apr 4, 11:53pm  

Another common drug might also work:

https://www.breitbart.com/border/2020/04/04/common-anti-parasite-drug-may-kill-coronavirus-in-under-48-hours-say-researchers/

Researchers in Australia report that Ivermectin, an FDA-approved drug commonly used to treat parasites, appears to be effective in treating the SARS-COV-2 coronavirus (COVID-19). The drug is widely available and can be “repurposed” for this application, doctors said.

The ScienceDirect journal, Antiviral Research, published an article by a group of Australian researchers from Monash University in Melbourne reporting that Ivermectin appears to be effective at inhibiting the coronavirus that causes COVID-19.

The article states:

Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro.
A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture.
Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing.
Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.
188   Tenpoundbass   2020 Apr 5, 6:27am  

It is amazing how everyone is dancing around the truth and racing to come up with an alternative for Chloroquine, because I'll be damned if they'll allow that Pompous Frog to get all of the credit for saving the World.

These people all need to be locked up and fed nothing but baloney and processed cheese.
189   Patrick   2020 Apr 5, 10:49am  

https://www.acsh.org/news/2020/03/26/problem-remdesivir-making-it-14665

Here's the important point of this article:

Two of the experimental coronavirus drugs, chloroquine, and hydroxychloroquine are a breeze to synthesize.


There should never be any real shortages of those.
190   HeadSet   2020 Apr 5, 11:41am  

Two of the experimental coronavirus drugs, chloroquine, and hydroxychloroquine are a breeze to synthesize.

No bear bile needed?
191   Patrick   2020 Apr 5, 11:50am  

Cool dashboard of clinical trials:

https://www.quiverquant.com/covidtreatments/
192   Rin   2020 Apr 5, 11:55am  

Ok, here is all that's needed, and just to be politically correct, the following is not approved by the FDA, it's just someone's speculation:

From the Russian-American doctor in NY... Zinc Sulfate, found in cold lozenges.

From the United Kingdom, active ingredient in garlic, Allicin: purified, stable, and bio-available. And for the trolls, not cooked or aged Garlic as all the Allicin there is gone. So please dispense with that bullshit rigged Stanford study. Here's the British website ( https://www.allicin.co.uk/section.php/2/1/about_us )

And now, for the main character in the play, Hydroxychloroquine, a.k.a Plaquenil.

This is it! And for a safety test, doctors can run an EKG on a patient, before and after, administrating a 25% dose of Plaquenil to see the person's physiology can handle it.
194   mell   2020 Apr 5, 10:22pm  

Yep. And here despicable leftoid lamestream media, the failing NYT: Orange man bad! pushing dangerous unproven drugs! Waah!

https://www.nytimes.com/2020/04/05/world/coronavirus-live-news-updates.html
195   marcus   2020 Apr 5, 10:49pm  

:
http://theconversation.com/a-small-trial-finds-that-hydroxychloroquine-is-not-effective-for-treating-coronavirus-135484

This talks about much more than that one small study. But who knows, maybe he's a paid shill by big pharma. Or maybe not.
197   Tenpoundbass   2020 Apr 6, 7:37am  

This really is a battle to the death, the Commie Democrats wants millions of deaths. Hang these mother fuckers until they shit their pants when it is proved that Trump Pills work and more importantly They Fucking Know it Does!

https://www.breitbart.com/politics/2020/04/06/democrat-tavia-galonski-trump-chloroquine-crimes-against-humanity/
198   Patrick   2020 Apr 6, 8:44am  

https://www.lemonde.fr/afrique/article/2020/04/06/l-afrique-potentiel-prochain-foyer-du-coronavirus-mise-sur-la-chloroquine_6035668_3212.html

Patients treated with hydroxychloroquine "heal faster," said Professor Moussa Seydi, head of the infectious disease department at Fann Hospital in Dakar, during a public address Thursday, April 2. “This finding reassures me and my teams. In the coming days, we are going to combine it with azithromycin, an antibiotic that would allow us to have better results, "he continued.
199   WookieMan   2020 Apr 6, 8:53am  

Patrick says
https://www.lemonde.fr/afrique/article/2020/04/06/l-afrique-potentiel-prochain-foyer-du-coronavirus-mise-sur-la-chloroquine_6035668_3212.html

Patients treated with hydroxychloroquine "heal faster," said Professor Moussa Seydi, head of the infectious disease department at Fann Hospital in Dakar, during a public address Thursday, April 2. “This finding reassures me and my teams. In the coming days, we are going to combine it with azithromycin, an antibiotic that would allow us to have better results, "he continued.

Wait until the first person is diagnosed as dying from the drug though because of a 1 in a million side effect and underlying condition. It's coming. Get the popcorn ready.
200   socal2   2020 Apr 6, 8:54am  

More "anecdotal" evidence.

*LA doctor seeing success with hydroxychloroquine to treat COVID-19*
Dr. Anthony Cardillo said he has seen very promising results when prescribing hydroxychloroquine in combination with zinc for the most severely-ill COVID-19 patients.

"Every patient I've prescribed it to has been very, very ill and within 8 to 12 hours, they were basically symptom-free," Cardillo told Eyewitness News. "So clinically I am seeing a resolution."
https://abc7.com/coronavirus-drug-covid-19-malaria-hydroxychloroquine/6079864/
201   Bd6r   2020 Apr 6, 1:07pm  

thomasdong1776 says
Fauci: no evidence anti-malaria drug pushed by Trump works against novel coronavirus

https://www.theguardian.com/world/2020/apr/05/coronavirus-fauci-trump-anti-malaria-drug

Let's see what Fauci says:

“In terms of science, I don’t think we can definitively say it works,” he told CBS’s Face the Nation.

“The data are really just at best suggestive. There have been cases that show there may be an effect and there are others to show there’s no effect.”

That does not qualify as Fauci saying that there is no evidence. He says "I don't think we can definitely say it works" which is different from headline and narrative of article, which, once more, shows that media are idiotic hacks.

Also, FDA says differently: https://www.fda.gov/media/136534/download

Based on the totality of scientific evidence available to FDA, it is reasonable to believe that chloroquine phosphate and hydroxychloroquine sulfate may be effective in treating COVID-19, and that, when used under the conditions described in this authorization, the known and potential benefits of chloroquine phosphate and hydroxychloroquine sulfate when used to treat COVID-19 outweigh the known and potential risks of such products.
202   rdm   2020 Apr 6, 2:28pm  

rd6B says
Based on the totality of scientific evidence available to FDA, it is reasonable to believe that chloroquine phosphate and hydroxychloroquine sulfate may be effective in treating COVID-19, and that, when used under the conditions described in this authorization, the known and potential benefits of chloroquine phosphate and hydroxychloroquine sulfate when used to treat COVID-19 outweigh the known and potential risks of such products.


All this says is that the FDA is now a politicized agency, really it always has been. Because " the totality of [real]scientific evidence available to FDA" is almost zero. Yes, there is the suggestion that it may have some effect, maybe a great effect and maybe no effect and it could simply be the placebo effect which can be significant. And Fauci is walking on eggshells, guarantee if Trump wasn't so gung ho on this he would be much harsher in his characterization of the purported treatment. Now I hear Trump is talking to Dr. Ozz and his trade rep Navaro and Rudi Giuliani as experts on the subject, hmmm doesn't that give one pause? Fortunately there are some real studies going on now, saw a guy from the University of Minnesota was working on two true double blind studies. Preliminary results may be fairly soon. I really hope it is effective as its cheap and available with side effects that are significant but usually tolerable, but will wait for the scientists to make that determination.
203   Bd6r   2020 Apr 6, 2:37pm  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC300808/

BMJ. 2003 Dec 20; 327(7429): 1459–1461.
doi: 10.1136/bmj.327.7429.1459

Objectives To determine whether parachutes are effective in preventing major trauma related to gravitational challenge.

Design Systematic review of randomised controlled trials.

Data sources: Medline, Web of Science, Embase, and the Cochrane Library databases; appropriate internet sites and citation lists.

Study selection: Studies showing the effects of using a parachute during free fall.

Main outcome measure Death or major trauma, defined as an injury severity score > 15.

Results We were unable to identify any randomised controlled trials of parachute intervention.

Conclusions As with many interventions intended to prevent ill health, the effectiveness of parachutes has not been subjected to rigorous evaluation by using randomised controlled trials. Advocates of evidence based medicine have criticised the adoption of interventions evaluated by using only observational data. We think that everyone might benefit if the most radical protagonists of evidence based medicine organised and participated in a double blind, randomised, placebo controlled, crossover trial of the parachute.
204   socal2   2020 Apr 6, 2:47pm  

*Detroit Democrat rep says hydroxychloroquine, Trump helped save her life amid COVID-19 fight*

LANSING — A Democratic state representative from Detroit is crediting hydroxychloroquine — and Republican President Donald Trump who touted the drug — for saving her in her battle with the coronavirus.

State Rep. Karen Whitsett, who learned Monday she has tested positive for COVID-19, said she started taking hydroxychloroquine on March 31, prescribed by her doctor, after both she and her husband sought treatment for a range of symptoms on March 18.

"It was less than two hours" before she started to feel relief, said Whitsett, who had experienced shortness of breath, swollen lymph nodes, and what felt like a sinus infection. She is still experiencing headaches, she said.

Whitsett said she was familiar with "the wonders" of hydroxychloroquine from an earlier bout with Lyme disease, but does not believe she would have thought to ask for it, or her doctor would have prescribed it, had Trump not been touting it as a possible treatment for COVID-19.

https://www.freep.com/story/news/local/michigan/detroit/2020/04/06/democrat-karen-whitsett-coronavirus-hydroxychloroquine-trump/2955430001/
205   EBGuy   2020 Apr 6, 2:52pm  

The last part of the story if interesting too. If State Rep. Whitsett makes a full recovery, she'll likely have a lot of visibility as she is able to move about freely.
She said too many people in Detroit are still not taking the virus seriously, and that needs to change.
"I see it in my own community — not being quarantined and still having house parties," she said.
Asked what she thinks of Trump's handling of the pandemic more generally, Whitsett said she credits Detroit Mayor Mike Duggan's relationship with Trump for helping to get the city what it needs to fight the virus.
206   marcus   2020 Apr 6, 2:55pm  

rd6B says
Also, FDA says differently: https://www.fda.gov/media/136534/download


Two things, one, thats 9 days ago, and yes they approved it for use.

The other is that stories have come out since questioning it's efficacy. They are small tests, and several tests before questioned it. The ones that were hopeful, like the one by the french hippy were just silly. A high percentage were not even symptomatic.

socal2 says
"Every patient I've prescribed it to has been very, very ill and within 8 to 12 hours, they were basically symptom-free," Cardillo told Eyewitness News. "So clinically I am seeing a resolution."


Right, but we know that 98% get better anyway.

Maybe with zinc alone it's 99.5% that get better, and 95% if you're over 80%. We just don't know.

I know, in these times, given the greed of big pharma it's easy to wish that neither science or statistics were a thing (talkng to tpb) .
207   Shaman   2020 Apr 6, 4:03pm  

rdm says
. I really hope it is effective as its cheap and available with side effects that are significant but usually tolerable, but will wait for the scientists to make that determination.


Bullshit! If you had the Rona and couldn’t fucking breathe, you’d suddenly develop an appreciation for fast tracking medical use of a prescription drug that’s been in use for 70 fucking years!
STFU about double blind methodology when it absolutely MANDATES that we kill a few hundred people whom we could have saved.
208   rdm   2020 Apr 6, 4:40pm  

Shaman says
Bullshit! If you had the Rona and couldn’t fucking breathe, you’d suddenly develop an appreciation for fast tracking medical use of a prescription drug that’s been in use for 70 fucking years!


Just because you are hysterical dont project that on me. If I get to the point of needing a ventilator my directive says no. But of course being hysterical you probably haven't studied what can happen when you get put on a ventilator. It is really something to avoid. And there are worse things than dying. As to the drug don't know whether I would take it or not. Like I said I hope it works. But by dissing double blind studies you only show your ignorance.

As scientists search for effective meds many things need to be tested, why put all your eggs in this basket? Antivirals are difficult to develop, did we get lucky and have a drug that works on this particular novel virus? Of course it's possible but most reputable scientists say it would be a huge stroke of luck, the odds are very much against it.
209   mell   2020 Apr 6, 7:10pm  

It's interesting how people (leftoids) insist on year long double blinded trials to prove a drug in use for almost a century which most likely does help with Covid-19, but then trumpet out lout projections of hundreds of thousands if not millions of people dying based on mathematically/statistically completely unsound assumptions where they have the luxury and the time to look for factual data instead. When projecting that millions die confidence intervals and hazard ratios suddenly don't matter, only when someone is on the fritz and makes a conscious choice then it's cool to deny them their wish based on not-carried out double-blinded studies.
210   Bd6r   2020 Apr 6, 7:33pm  

marcus says
Two things, one, thats 9 days ago, and yes they approved it for use.

Desperate times require desperate measures. If they would not have at least some indications that it works, they would not have approved. How efficient this thing is, is a whole another question.

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