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Picture evidence shows that the distance between the Wuhan Institute of Virology of the Communist Party of China and the Pfizer Vaccine R&D Center Building where the new coronavirus vaccine is developed is only 20 kilometers
图片证据显示中共武汉病毒所与研制新冠疫苗的辉瑞大厦 辉瑞疫苗研发中心大厦的距离仅20公里

The journalist interviewed a witness who had experienced the COVID lockdowns in China. The person stated that they were forcibly given three doses of the COVID-19 vaccine and required to undergo weekly PCR testing, with swabs inserted deep into the throat.

The journalist asked: “Why not use saliva-based testing instead?”

The interviewee replied: “This is mandated by law. Raising objections could result in brutal persecution or even death threats!”

The interviewee recounted: “I was originally very healthy. After receiving the vaccine, I constantly felt fatigued. Colds and inflammation became noticeably more frequent and harder to recover from. I also developed certain food allergies and gastrointestinal discomfort.”

The journalist stated: “The so-called COVID-19 vaccines and PCR tests are intended to deliberately implant spike-protein nano-pathogens into the human body. The anti-human lies and persecution are obvious!”

In an editorial, the journalist wrote: “Regarding the human rights disasters occurring under the authoritarian regime of the Chinese Communist Party and in Iran, the international democratic community must pay close attention, strongly condemn them, and must never appease or tolerate them.

In 2020, after years of research in Wuhan, China, and deliberate release and deployment, the CCP virus originating from China and the COVID-19 vaccines became concrete instruments of persecution in an unrestricted warfare strategy of international communism against the world.

The Wuhan Institute of Virology is only 20 kilometers away from a Pfizer research and development center building. Therefore, promoting democracy and freedom is saving people from danger. In combating global terrorism, the first priority is to oppose authoritarian dictatorship, because authoritarian dictatorship is the root of ideological terror. It shelters and enables crime, allowing evil to spread and endanger all humanity. This is the significance of opposing communism and opposing authoritarian dictatorship.”

/ France: Freedom, Health, Human Rights Journalist: Han Rongli

记者采访了曾经在中国经历疫情封闭社区见证人、当事人被强制施打三针新冠疫苗及每周一次PCR测试棒深入喉咙检测。记者问：为什么不用唾液体外检测？当事人：这是法律规定，提出异议会遭到残酷迫害甚至死亡威胁！当事人叙述：原来身体很健康，施打疫苗后总是感觉疲劳，感冒炎症明显增多而且不容易康复，还出现部分食品过敏及肠胃不适问题。记者：所谓的新冠疫苗与PCR检测、其目的都是蓄意植入人体刺突蛋白奈米病原体，反人类谎言迫害昭然若揭！…记者社论：对于发生在独裁专制中共国及伊朗的人权灾难，国际民主社会要密切关注、强烈谴责，绝不能绥靖纵容。2020年经过了在中国武汉多年研制、蓄意投放布局的始源于中国的中共病毒🦠与新冠疫苗💉，就是国际共产主义超限战对全球布局迫害的统战的具体迫害手段。中共武汉病毒研究所与辉瑞研发中心大厦距离仅仅20公里。所以！推动民主自由就是救人于危难！世界反恐首先要反对独裁专制，因独裁专制就是主义恐怖的根源，独裁专制纵容罪恶藏污纳垢，其罪恶会肆虐蔓延危害全球人类，反共反独裁专制的意义尽在于此！/ 法国：自由健康人权记者：韩荣利

Long COVID May Be a Systemic Microvascular Disease: How SPED (Spike Protein Endothelial Disease) May Explain “Post-COVID Anxiety”
A very interesting paper from 2021 demonstrates how SARS-CoV-2 (read Spike Protein) may induce stress-related disorders.
WALTER M CHESNUT
FEB 23
长期新冠病毒可能是一种全身性微血管疾病：SPED（尖峰蛋白内皮疾病）如何解释“新冠病毒后焦虑”
2021 年一篇非常有趣的论文展示了 SARS-CoV-2（读作刺突蛋白）如何诱发与压力相关的疾病。
沃尔特·M·切斯纳特
2月23日

https://open.substack.com/pub/wmcresearch/p/long-covid-may-be-a-systemic-microvascular

Long COVID May Be a Systemic Microvascular Disease: How SPED (Spike Protein Endothelial Disease) May Explain “Post-COVID Anxiety”
A very interesting paper from 2021 demonstrates how SARS-CoV-2 (read Spike Protein) may induce stress-related disorders.
WALTER M CHESNUT
FEB 23

READ IN APP

The SARS-CoV-2 virus triggers endothelial senescence by usurping host serine proteases, the renin angiotensin system, and mitochondria.
Senescent endothelial cells disrupt the BBB tight junctions, allowing stress molecules, including ANGc II, ET-1 and PAI-1, access to the amygdala, hippocampus, and mPFC, increasing the susceptibility for PTSD and other stress related disorders.
Virus-damaged mitochondria predispose to PTSD by shifting cellular metabolism from OXPHOS to glycolysis in a Warburg effect.
Virus-usurped furin and plasmin alter the pro-BDNF/BDNF ratio, predisposing to PTSD.
In the above set of bullet points – let’s be real. The first one should most certainly begin with “The SARS-CoV-2 Spike Protein triggers endothelial senescence...”

One of the more unusual aspects of Long COVID is the development of what has been called Post-COVID Anxiety.

Anxiety is considered one of the longer-term symptoms of Post-COVID syndrome (PCS), aka Long-COVID — a recently identified diagnosis.

Research shows that between 23% and 26% of people have mental health challenges (including anxiety) after recovering from the disease, particularly females.

Some studies place that figure higher, hovering closer to the 50% mark.

Post-COVID anxiety has overlapping symptoms with other mental health conditions, including:

generalized anxiety disorder (GAD)
obsessive-compulsive disorder (OCD)
post-traumatic stress disorder (PTSD)
major depressive disorder (MDD)
Illness anxiety
panic disorder
Post-COVID Anxiety: An Emerging Condition
https://psychcentral.com/anxiety/anxiety-after-covid

This intrigued me, as I believe it may actually be a manifestation of what I have called SPED (Spike Protein Endothelial Disease). Let’s go back to 2015. A study was published that showed a definitive relationship between higher anxiety levels and the incidence of stroke.

Results

A total of 419 incident stroke cases were identified from hospital/nursing home discharge reports and death certificates. Reporting more anxiety symptoms at baseline was associated with increased risk of incident stroke after adjusting for standard biological and behavioral cardiovascular risk factors (hazard ratio, 1.14; 95% confidence interval, 1.03–1.25). Findings persisted when additionally controlling for depression. Exploratory analyses considering the role of potential confounding versus pathway variables suggested that behavioral factors may be a key pathway linking anxiety to stroke risk.

Conclusions

Higher anxiety symptom levels were associated prospectively with increased risk for incident stroke independent of other risk factors, including depression. Anxiety is a modifiable experience that is highly prevalent among the general population. Its assessment and treatment may contribute to developing more effective preventive and intervention strategies for improving overall cardiovascular health.

Prospective Study of Anxiety and Incident Stroke
https://pmc.ncbi.nlm.nih.gov/articles/PMC4354776/

So, we have a correlation between anxiety and stroke – microvascular disease. Now, let us look at a 2021 paper which demonstrates that PTSD is itself an endothelial disease. The mechanisms involve BBB disruption and endothelial cell senescence – well known as part of the Spike Protein’s repertoire.

COVID-19 has been associated with a high PTSD prevalence, suggesting that aside from the psychological burden of the disease itself, the virus may directly interfere with the stress-processing brain areas. The virus-host interactome reveals several pathogen-induced states, such as cellular senescence and associated glycolysis, that facilitate viral replication, while at the same time disrupt the BBB. The virus likely increases PTSD susceptibility as, even in the absence of viral infection, this disorder has been associated with EC senescence and glycolytic states. This two-strike model not only may explain the high comorbidity of COVID-19 and PTSD, but also opens vistas for novel interventions, including ARBs, ACEi, ASIC1a blockers, senolytics, furin inhibitors, BRD4 inhibitors and anti-glycolytic interventions.

PTSD as an Endothelial Disease: Insights From COVID-19
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.770387/full

What do these findings tell us? Essentially, they begin to build a hi-resolution image showing Long COVID being a microvascular disease. And a systemic one at that. This leads to several questions. Among the most important being; is it reversible? Another that I am continually researching is centered on the whole subclinical nature of microvascular disease. Is this happening, more or less, to anyone who has been exposed to SARS-CoV-2 and/or its Spike Protein? After all, smoking causes subclinical damage long before clinical signs develop. The same is true for many other chronic – and fatal – conditions. I will continue the search for truth and understanding. Please have a blessed week.

长新冠可能是一种全身性微血管疾病：SPED（刺突蛋白内皮疾病）如何解释“新冠后焦虑”

一篇发表于2021年的非常有意思的论文表明，SARS-CoV-2（可理解为刺突蛋白）可能会诱发与压力相关的疾病。
作者：WALTER M CHESNUT
2月23日

⸻

SARS-CoV-2 病毒通过劫持宿主丝氨酸蛋白酶、肾素-血管紧张素系统以及线粒体，触发内皮细胞衰老。

衰老的内皮细胞会破坏血脑屏障（BBB）的紧密连接，使包括 ANGc II、ET-1 和 PAI-1 在内的应激分子进入杏仁核、海马体和内侧前额叶皮层（mPFC），从而增加创伤后应激障碍（PTSD）及其他压力相关疾病的易感性。

病毒损伤的线粒体通过将细胞代谢从氧化磷酸化（OXPHOS）转向糖酵解（即“瓦尔堡效应”），使个体更易罹患 PTSD。

病毒劫持的 furin 和 plasmin 会改变 pro-BDNF/BDNF 的比例，从而增加 PTSD 的风险。

在上述要点中——坦率地说，第一条几乎可以肯定应改为：“SARS-CoV-2 的刺突蛋白触发内皮细胞衰老……”

⸻

长新冠较为特殊的一个方面，是出现所谓的“新冠后焦虑”。

焦虑被认为是新冠后综合征（PCS），亦称长新冠的一种长期症状——这是一种近期才被识别的诊断。

研究显示，约有 23% 至 26% 的人在康复后会出现心理健康问题（包括焦虑），女性尤为明显。

一些研究甚至将这一比例估计接近 50%。

新冠后焦虑与其他心理健康疾病存在症状重叠，包括：
• 广泛性焦虑障碍（GAD）
• 强迫症（OCD）
• 创伤后应激障碍（PTSD）
• 重度抑郁障碍（MDD）
• 疾病焦虑障碍
• 惊恐障碍

《新冠后焦虑：一种新兴状况》
https://psychcentral.com/anxiety/anxiety-after-covid

这引起了我的兴趣，因为我认为这实际上可能是我所称的 SPED（刺突蛋白内皮疾病）的一种表现。让我们回到2015年。当年发表的一项研究显示，更高的焦虑水平与中风发生率之间存在明确关联。

结果

通过医院/护理机构出院报告和死亡证明，共确认419例新发中风病例。基线时报告更多焦虑症状，与新发中风风险增加相关，即使在调整标准的生物学和行为性心血管风险因素后仍然如此（风险比1.14；95%置信区间1.03–1.25）。在进一步控制抑郁因素后，这一结果依然存在。探索性分析显示，行为因素可能是将焦虑与中风风险联系起来的关键路径。

结论

较高的焦虑症状水平与未来中风风险增加相关，这种关联独立于包括抑郁在内的其他风险因素。焦虑是一种在普通人群中高度普遍、且可以干预的状态。对其进行评估和治疗，或有助于制定更有效的预防与干预策略，从而改善整体心血管健康。

《焦虑与新发中风的前瞻性研究》
https://pmc.ncbi.nlm.nih.gov/articles/PMC4354776/

因此，我们看到焦虑与中风（微血管疾病）之间存在关联。接下来看看2021年的另一篇论文，该研究表明 PTSD 本身是一种内皮疾病，其机制涉及血脑屏障破坏和内皮细胞衰老——而这些正是刺突蛋白众所周知的作用机制之一。

新冠疫情与较高的 PTSD 患病率相关，这提示除了疾病本身带来的心理负担外，病毒可能直接干扰大脑的压力处理区域。病毒-宿主相互作用网络揭示出多种由病原体诱导的状态，例如细胞衰老及其相关的糖酵解，这些状态既有利于病毒复制，同时也会破坏血脑屏障。即便在没有病毒感染的情况下，PTSD 也与内皮细胞衰老和糖酵解状态有关。因此，这种“双重打击模型”不仅可能解释 COVID-19 与 PTSD 的高度共病，还为新的干预方式提供了方向，包括 ARBs、ACE 抑制剂、ASIC1a 阻断剂、清除衰老细胞药物、furin 抑制剂、BRD4 抑制剂以及抗糖酵解干预等。

《PTSD 作为一种内皮疾病：来自 COVID-19 的启示》
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.770387/full

这些发现告诉我们什么？本质上，它们开始构建一幅更高分辨率的图景，显示长新冠可能是一种微血管疾病，而且是全身性的。这引出了若干问题，其中最重要的包括：它是否可逆？

另一个我持续研究的问题，是微血管疾病的亚临床性质。是否任何接触过 SARS-CoV-2 及/或其刺突蛋白的人，或多或少都会发生这种情况？毕竟，吸烟在临床症状出现之前就会造成亚临床损伤。许多其他慢性甚至致命疾病也是如此。

我将继续寻找真相与理解。祝大家一周平安。